Korean J Psychopharmacol.
2012 Apr;23(2):45-50.
Serotonin Outside the Central Nervous System
- Affiliations
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- 1Department of Psychiatry, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea. wmbahk@catholic.ac.kr
Abstract
- Most serotonin is found outside the central nervous system and functions much more than a neurotransmitter. Peripheral serotonin is produced by enterochromaffin cells in the gastrointestinal tract and secreted into blood. Serotonin, as a circulating amine, takes part in numerous biological processes including cardiovascular function, bowel motility, glucose metabolism and skeletal change. Serotonin signaling is regulated by serotonin receptors and serotonin transporters in multiple body organs. The drugs that manipulate the serotonergic system have been developed and used for the treatment of many systemic diseases. The richness of serotonergic modulation in the whole body provide both a pharmacologic opportunity and challenge.
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