Exp Neurobiol.  2011 Dec;20(4):159-168. 10.5607/en.2011.20.4.159.

The Serotonin-6 Receptor as a Novel Therapeutic Target

Affiliations
  • 1Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 136-791, Korea. hrhim@kist.re.kr

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that is found in both the central and peripheral nervous systems. 5-HT mediates its diverse physiological responses through 7 different 5-HT receptor families: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 receptors. Among them, the 5-HT6 receptor (5-HT6R) is the most recently cloned serotonin receptor and plays important roles in the central nervous system (CNS) and in the etiology of neurological diseases. Compared to other 5-HT receptors, the 5-HT6R has been considered as an attractive CNS therapeutic target because it is expressed exclusively in the CNS and has no known isoforms. This review evaluates in detail the role of the 5-HT6R in the physiology and pathophysiology of the CNS and the potential usefulness of 5-HT6R ligands in the development of therapeutic strategies for the treatment of CNS disorders. Preclinical studies provide support for the use of 5-HT6R ligands as promising medications to treat the cognitive dysfunction associated with Alzheimer's disease, obesity, depression, and anxiety.

Keyword

depression; Alzheimer; cognitive disorders; Fyn; Jab1; ST1936

MeSH Terms

Alzheimer Disease
Anxiety
Central Nervous System
Clone Cells
Depression
Ethylamines
Indoles
Ligands
Neurotransmitter Agents
Obesity
Peripheral Nervous System
Protein Isoforms
Receptors, Serotonin
Serotonin
Ethylamines
Indoles
Ligands
Neurotransmitter Agents
Protein Isoforms
Receptors, Serotonin
Serotonin
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