Anesth Pain Med.
2015 Oct;10(4):267-270. 10.17085/apm.2015.10.4.267.
A case of postoperative serotonin syndrome following the administration of fentanyl, palonosetron, and meperidine: A case report
- Affiliations
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- 1Department of Anesthesiology and Pain Medicine, Daegu Fatima Hospital, Daegu, Korea. kej1127@fatima.or.kr
- 2Department of Psychiatry, Ulsan University Hospital, Ulsan, Korea.
- KMID: 2148011
- DOI: http://doi.org/10.17085/apm.2015.10.4.267
Abstract
- Serotonin syndrome is an unexpected adverse reaction of serotonergic medication. Some drugs used by anesthesiologists may cause serotonin syndrome. Serotonin syndrome is known to be related to 5-hydroxytryptamine 1A and 5-hydroxytryptamine 2A agonism. However, recent research has revealed evidence that 5-hydroxytryptamine 3 (5-HT3) antagonism can also play a role in serotonin syndrome. Among the 5-HT3 antagonists, palonosetron is the most highly specific. In this study, we present the first case of fentanyl- and meperidine-induced serotonin syndrome precipitated by palonosetron in general anesthesia.
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