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Dexmedetomidine and LPS co-treatment attenuates inflammatory response on WISH cells via inhibition of p38/NF-kB signaling pathway

Kim TS, Yoon JY, Kim CH, Choi EJ, Kim YH, Kim EJ

Background: Inflammatory dental diseases that occur during pregnancy can cause preterm labor and/or intrauterine growth restriction. Therefore, proactive treatment of dental diseases is necessary during pregnancy. Dexmedetomidine (DEX) is a...
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PRR16/Largen Induces Epithelial-Mesenchymal Transition through the Interaction with ABI2 Leading to the Activation of ABL1 Kinase

Kang GJ, Park JH, Kim HJ, Kim EJ, Kim B, Byun HJ, Yu L, Nguyen TM, Nguyen TH, Kim KS, Huy HP, Rahman M, Kim YH, Jang JY, Park MK, Lee H, Choi CI, Lee K, Han HK, Cho J, Rho SB, Lee CH

Advanced or metastatic breast cancer affects multiple organs and is a leading cause of cancer-related death. Cancer metastasis is associated with epithelial-mesenchymal metastasis (EMT). However, the specific signals that induce...
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Gynostemma pentaphyllum extract and its active component gypenoside L improve the exercise performance of treadmill-trained mice

Kim YH, Jung JI, Jeon YE, Kim SM, Hong SH, Kim TY, Kim EJ

BACKGROUND/OBJECTIVES: The effectiveness of natural compounds in improving athletic ability has attracted attention in both sports and research. Gynostemma pentaphyllum (Thunb.) leaves are used to make traditional herbal medicines in...
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Prognostic Value of Short-Term Followup of Multiple Biomarkers After Discharge in Hospitalized Patients With Acute Heart Failure (POSTBIO-HF): Rationale and Study Design

Cho DH, Son JW, Lee CJ, Choi J, Kim MN, Lee JH, Lee S, Yang DH, Cho HJ, Choi JO, Kim EJ, Choi DJ, Yoo BS

Several surrogate biomarkers possess prognostic significance for heart failure (HF), and a decline in their respective values may predict clinical improvement. However, data on the prognostic value of these biomarkers...
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Fetal Ascites Proven as Klippel-Trenaunay Syndrome after Birth: A Case Report

Kim HJ, Cho HJ, Kim EJ, Kim SY, Son DW

Fetal ascites may occur for various reasons, and the prognosis depends on the underlying pathology. Fetal chylous ascites is a rare form of fetal ascites that results from the leakage...
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Loss of EMP2 Inhibits Melanogenesis of MNT1 Melanoma Cells via Regulation of TRP-2

Enkhtaivan E, Kim HJ, Kim B, Byun HJ, Yu L, Nguyen TM, Nguyen TH, Do PA, Kim EJ, Kim KS, Huy HP, Rahman M, Jang JY, Rho SB, Lee H, Kang GJ, Park MK, Kim NH, Choi CI, Lee K, Han HK, Cho J, Lee AY, Lee CH

Melanogenesis is the production of melanin from tyrosine by a series of enzyme-catalyzed reactions, in which tyrosinase and DOPA oxidase play key roles. The melanin content in the skin determines...
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In vivo study for the hemostatic efficacy and foreign body reaction of a new powder-type polysaccharide hemostatic agent

Byun Y, Kim EJ, Lee A, Suh YA, Sohn HJ, Lee JM, Kang JS, Choi YJ, Han Y, Kim H, Kwon W, Jang JY

Purpose: Various hemostatic agents have been introduced in therapy as postoperative bleeding is a poor prognostic factor for postoperative outcomes. These products can be divided into those that directly promote...
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The Immunomodulating Effects of Thalidomide and Dexamethasone in a Murine Cardiac Allograft Transplantation Model

Kim SJ, Kim JY, Kim EJ, Lee H, Cho Y, Kim MS, Kim YS, Kim BS, Huh KH

Purpose: The immunomodulatory effects of thalidomide (TM) and dexamethasone (DX) on immune cells and their co-stimulatory, co-inhibitory molecules in vitro and in vivo have been previously reported. The current study...
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Gynostemma pentaphyllum extract and Gypenoside L enhance skeletal muscle differentiation and mitochondrial metabolism by activating the PGC-1α pathway in C2C12 myotubes

Kim YH, Jung JI, Jeon YE, Kim SM, Oh TK, Lee J, Moon JM, Kim TY, Kim EJ

BACKGROUND/OBJECTIVES: Peroxisome proliferator-activated receptor-gamma co-activator-1α (PGC-1α) has a central role in regulating muscle differentiation and mitochondrial metabolism. PGC-1α stimulates muscle growth and muscle fiber remodeling, concomitantly regulating lactate and lipid...
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Association Between Body Mass Index and Cognitive Function in Mild Cognitive Impairment Regardless of APOE ε4 Status

Mun YS, Park HK, Kim J, Yeom J, Kim GH, Chun MY, Lee HA, Yoon SJ, Park KW, Kim EJ, Yoon B, Jang JW, Hong JY, Choi SH, Jeong JH

Background and Purpose: In this study we aimed to find the association between neuropsychological performance and body mass index (BMI) in patients with mild cognitive impairment (MCI). In addition, we...
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Validation of age- and sex-dependent association of uric acid and incident hypertension in rural areas

Kim IJ, Kim W, Go TH, Kang DR, Kim JY, Kim EJ

Background: A previous study based on urban areas suggested the age- and sex-dependent association of uric acid (UA) and incident hypertension. We aimed to investigate whether this association is valid...
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Ureteral Stent Induced Urinary Tract Infection and Microbial Inconsistency Between Bladder and Renal Pelvis

Choi U, Kim EJ, Lyu DH, Park BH, Chung H, Han CH, Bae S

Purpose: This study examined the effects of long-term ureteral stent (US) on urinary tract infection (UTI) by bacterial migration and bacterial colonization. Materials and Methods: From March 2014 to August 2021,...
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Importation and Transmission of SARS-CoV-2 B.1.1.529 (Omicron) Variant of Concern in Korea, November 2021

Lee JJ, Choe YJ, Jeong H, Kim M, Kim S, Yoo H, Park K, Kim C, Choi S, Sim J, Park Y, Huh IS, Hong G, Kim MY, Song JS, Lee J, Kim EJ, Rhee JE, Kim IH, Gwack J, Kim J, Jeon JH, Lee WG, Jeong S, Kim J, Bae B, Kim JE, Kim H, Lee HY, Lee SE, Kim JM, Park H, Yu M, Choi J, Kim J, Lee H, Jang EJ, Lim D, Lee S, Park YJ

In November 2021, 14 international travel-related severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 (omicron) variant of concern (VOC) patients were detected in South Korea. Epidemiologic investigation revealed community transmission...
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Effective End-to-End Deep Learning Process in Medical Imaging Using Independent Task Learning: Application for Diagnosis of Maxillary Sinusitis

Oh JH, Kim HG, Lee KM, Ryu CW, Park S, Jang JH, Choi HS, Kim EJ

Purpose: This study aimed to propose an effective end-to-end process in medical imaging using an independent task learning (ITL) algorithm and to evaluate its performance in maxillary sinusitis applications. Materials and...
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Clinical and Laboratory Factors Associated with Symptom Development in Asymptomatic COVID-19 Patients at the Time of Diagnosis

Oh HS, Kim JH, Woo ML, Kim JY, Park CH, Won H, Lim S, Jeong H, Ham SY, Kim EJ, Sheen S, Kang YM, Yoon D, Lee SY, Song KH

In preparation for the surge of coronavirus disease 2019 (COVID-19), it is crucial to allocate medical resources efficiently for distinguishing people who remain asymptomatic until the end of the disease....
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Lomens-P0 (mixed extracts of Hordeum vulgare and Chrysanthemum zawadskii) regulate the expression of factors affecting premenstrual syndrome symptoms

Lee YS, Jeon H, Her YM, Lee DE, Jeong YJ, Kim EJ, Choe TH, Suh HJ, Shin SY, Park DW, Lee YG, Kang SC

BACKGROUND/OBJECTIVES: Premenstrual syndrome (PMS) is a disorder characterized by repeated emotional, behavioral, and physical symptoms before menstruation, and the exact cause and mechanism are uncertain. Hyperprolactinemia interferes with the normal...
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Heart Failure Statistics in Korea, 2020: A Report from the Korean Society of Heart Failure

Park JJ, Lee CJ, Park SJ, Choi JO, Choi S, Park SM, Choi EY, Kim EJ, Yoo BS, Kang SM, Park MH, Lee J, Choi DJ

Background and Objectives: Heart failure (HF) is a disease with high morbidity and mortality. With ageing society and increasing prevalence of risk factors of HF, the prevalence of HF is...
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Correlation between Exposure to Fine Particulate Matter (PM 2.5 ) during Pregnancy and Congenital Anomalies: Its Surgical Perspectives

Koo Ej, Bae JG, Kim EJ, Cho YH

Background Fine particulate matter (PM2.5) can easily penetrate blood vessels and tissues through the human respiratory tract and cause various health problems. Some studies reported that particular matter (PM) exposure during...
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The Influence of Women Dental Hygienists’ Work–Family Balance on Happiness Level in Dental Clinics

Im AJ, Kim Yw, Kim Sj, Kim Sy, Kim Ej, Moon Sd, Shin Sm, Jeong Hi, Jeong HA, Lim HJ

Background: To identify work–family balance and level of happiness among married women dental hygienists in Seoul and Gyeonggi Province. The goal of this study is to use the outcome as...
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Effects of Depression and Resilience of Public Workers on Work-related Stress and Anxiety in Response to the COVID-19 Pandemic

Ju G, Lee J, Ahn MH, Lee J, Kim EJ, Suh S, Chung S

Background: This study explored the clinical variables related to public workers' stress and anxiety regarding the viral epidemic, and the mediating effect of resilience on the relationship between their depression...
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