Korean J Anesthesiol.  1997 Jun;32(6):985-989. 10.4097/kjae.1997.32.6.985.

A Comparison of Fentanyl and Meperidine as Utilized in Patient Controlled Analgesia after Total Abdominal Hysterectomy

• Kim DH
• Kim SH

• KMID: 2237764
• DOI: http://doi.org/10.4097/kjae.1997.32.6.985

Abstract

BACKGROUND
We compared the dose requirement, analgesic effect and side effects of fentanyl with those of meperidine when administered by patient controlled analgesia(PCA) with ketorolac after total abdominal hysterectomy.
METHODS
Patients received ketorolac(bolus dose 1.5 mg, lockout interval 10 min) with either fentanyl(bolus dose 5 mcg) or meperidine(bolus dose 5 mg) using PCA pump postoperatively.
RESULTS
During 48hrs, patients receiving fentanyl used significantly more drug(51.2 mg of morphine) than those receiving meperidine(25.4 mg of morphine) when results were expressed as morphine(mg) equivalents using the putative potency ratios of 1:10:0.01(morphine:meperidine:fentanyl). There were no significant differences in incidences of side effects, but analgesic effect of fentanyl was superior to that of meperidine at 12 and 48 hours after operation.
CONCLUSIONS
Although both fentanyl and meperidine were useful and safe drugs for PCA for postoperative pain control, combinations of meperidine and ketorolac provided more effective analgesia.

Keyword

Analgesia; patient-controlled; postoperative; Analgesics; meperidine; fentanyl

MeSH Terms

Analgesia
Analgesia, Patient-Controlled*
Analgesics
Fentanyl*
Humans
Hysterectomy*
Incidence
Ketorolac
Meperidine*
Pain, Postoperative
Passive Cutaneous Anaphylaxis
Analgesics
Fentanyl
Ketorolac
Meperidine