Korean J Physiol Pharmacol.
1999 Jun;3(3):251-261.
Effects of carnosine and related compounds on monosaccharide autoxidation and H2O2 formation
- Affiliations
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- 1Laboratory of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Suwon, 441-744 South Korea.
- 2Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Suwon, 441-744 South Korea.
- 3Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Suwon 441-744, Korea.
- 4Department of Veterinary Physiology, College of Veterinary Medicine, Chungbuk National University, Cheongiu 361-763, Korea.
Abstract
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The effects of carnosine and related compounds (CRCs) including
anserine, homocarnosine, histidine, and beta-alanine on monosaccharide
autoxidation and H2O2 formation were investigated. The incubation of
CRCs with D-glucose, D-glucosamine, and D, L-glyceraldehyde at
37degreeC increased the absorption maxima at 285 nm, 273 nm, and 290
~ 330 nm, respectively. D, L-glyceraldehyde was the most reactive
sugar with CRCs. The presence of copper strongly stimulated the
reaction of carnosine and anserine with D-glucose or D-glucosamine.
Carnosine and anserine stimulated H2O2 formation from D-glucose
autoxidation in a dose-dependent manner in the presence of 10 muM Cu
(II). The presence of human serum albumin (HSA) decreased their effect
on H2O2 formation. Carnosine and anserine has a biphasic effect on
alpha-ketoaldehyde formation from glucose autoxidation. CRCs inhibited
glycation of HSA as determined by hydroxymethyl furfural, lysine
residue with free epsilon-amino group, and fructosamine assay. These
results
suggest that CRCs may be protective against diabetic complications by reacting with sugars and protecting glycation of protein.
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