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Urinary Metabolites as Biomarkers for Diagnosis of Breast Cancer: A Preliminary Study

Park J, Shin Y, Kim TH, Kim DH, Lee A

PURPOSE: For early detection of breast cancer, tests with high sensitivity and specificity are needed. Metabolomics, the study of chemical processes involving metabolites, can be used to identify diagnostic biomarkers...
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A PAS-Containing Histidine Kinase is Required for Conidiation, Appressorium Formation, and Disease Development in the Rice Blast Fungus, Magnaporthe oryzae

Shin JH, Gumilang A, Kim MJ, Han JH, Kim KS

Rice blast disease, caused by the ascomycete fungus Magnaporthe oryzae, is one of the most important diseases in rice production. PAS (period circadian protein, aryl hydrocarbon receptor nuclear translocator protein,...
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Therapeutic Effects of Amino Acids in Liver Diseases: Current Studies and Future Perspectives

Lee DY, Kim EH

Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver and the third most common cause of cancer-related death worldwide. HCC is caused by infection of hepatitis...
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Scombroid Fish Poisoning and Histamine Food Poisoning

Chung SP

Scombroid fish poisoning (SFP) is a form of histamine food poisoning caused by the ingestion of improperly stored fish. The term “scombroid” derives from the family name of the fish...
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A two-component signal transduction system contributes to the virulence of Riemerella anatipestifer

Wang Q, Chen M, Zhang W

Similar to other studies of bacterial pathogens, current studies of the pathogenesis of Riemerella anatipestifer (RA) are focused mainly on in vitro culture conditions. To elucidate further the pathogenesis of...
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Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo

Kim S, Moon GJ, Oh YS, Park J, Shin WH, Jeong JY, Choi KS, Jin BK, Kholodilov N, Burke RE, Kim HJ, Ha CM, Lee SG, Kim SR

We recently reported that adeno-associated virus serotype 1 (AAV1) transduction of murine nigral dopaminergic (DA) neurons with constitutively active ras homolog enriched in brain with a mutation of serine to...
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Correlation Between Gastric Emptying and Gastric Adaptive Relaxation Influenced by Amino Acids

Uchida M, Kobayashi , Saito C

  • KMID: 2387831
  • J Neurogastroenterol Motil.
  • 2017 Jul;23(3):400-408.
  • doi: 10.5056/jnm16153
BACKGROUND/AIMS: Amino acids have many physiological activities. We report the correlation between gastric emptying and gastric adaptive relaxation using tryptophan and amino acids with a straight alkyl chain, hydroxylated chain,...
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Metabolomic analysis of healthy human urine following administration of glimepiride using a liquid chromatography-tandem mass spectrometry

Do EY, Gwon MR, Kim BK, Ohk B, Lee HW, Kang WY, Seong SJ, Kim HJ, Yoon YR

Glimepiride, a third generation sulfonylurea, is an antihyperglycemic agent widely used to treat type 2 diabetes mellitus. In this study, an untargeted urinary metabolomic analysis was performed to identify endogenous...
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Proposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90

Jun KY, Kwon Y

There is a conserved ATPase domain in topoisomerase II (topo II) and heat shock protein 90 (Hsp90) which belong to the GHKL (gyrase, Hsp90, histidine kinase, and MutL) family. The...
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Association of HLA Genotype and Fulminant Type 1 Diabetes in Koreans

Kwak SH, Kim YJ, Chae J, Lee CH, Han B, Kim JI, Jung HS, Cho YM, Park KS

Fulminant type 1 diabetes (T1DM) is a distinct subtype of T1DM that is characterized by rapid onset hyperglycemia, ketoacidosis, absolute insulin deficiency, and near normal levels of glycated hemoglobin at...
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Identification of a New Selective Chemical Inhibitor of Mutant Isocitrate Dehydrogenase-1

Kim HJ, Choi BY, Keum YS

BACKGROUND: Recent genome-wide sequencing studies have identified unexpected genetic alterations in cancer. In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed...
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Genome-Wide Identification and Characterization of Novel Laccase Genes in the White-Rot Fungus Flammulina velutipes

Kim HI, Kwon OC, Kong WS, Lee CS, Park YJ

The aim of this study was to identify and characterize new Flammulina velutipes laccases from its whole-genome sequence. Of the 15 putative laccase genes detected in the F. velutipes genome,...
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SLC26A4 Mutations in Korean Population

Kim BG

SLC26A4 mutations are common cause of congenital hearing loss in East Asia. The carrier frequency of SLC26A4 mutations is 1 in 75 in Korean populations. The SLC26A4 mutation spectrum varies...
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Evaluation of the genotoxicity of ginseng leaf extract UG0712

Kim JY, Ri Y, Do SG, Lee YC, Park SJ

Although ginseng (genus Panax) leaf extract contains high concentrations of bioactive constituents, its effects have been reported in few preclinical studies, and information regarding its toxicity is not sufficient to...
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Biological functions of histidine-dipeptides and metabolic syndrome

Song BC, Joo NS, Aldini G, Yeum KJ

  • KMID: 2313704
  • Nutr Res Pract.
  • 2014 Feb;8(1):3-10.
The rapid increase in the prevalence of metabolic syndrome, which is associated with a state of elevated systemic oxidative stress and inflammation, is expected to cause future increases in the...
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Biodistribution of 99mTc Labeled Integrin Antagonist

Jang BS, Park SH, Shin IS, Maeng JS, Paik CH

  • KMID: 2317812
  • Toxicol Res.
  • 2013 Mar;29(1):21-25.
The selective targeting of an integrin alphavbeta3 receptor using radioligands may enable the assessment of angiogenesis and integrin alphavbeta3 receptor status in tumors. The aim of this research was to...
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pncA Mutations in the Specimens from Extrapulmonary Tuberculosis

Lee J, Yun YJ, Kqueen CY, Lee JH, Kim HY, Kim YR, Kook YH, Lee KH

  • KMID: 2319847
  • Tuberc Respir Dis.
  • 2012 Jun;72(6):475-480.
BACKGROUND: Pyrazinamide (PZA) is an effective antitubercular drug that becomes toxic to Mycobacterium tuberculosis when converted to pyrazinoic acid by pyrazinamidase (PZase), encoded by mycobacterial pncA. A strong association was...
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An Arg528His Mutation of the CACNL1A3 Gene in a Korean Family with Hypokalemic Periodic Paralysis

Kim KR, Suh ES, Lee YM

  • KMID: 2043932
  • J Korean Child Neurol Soc.
  • 2012 Mar;20(1):28-32.
Familial hypokalemic periodic paralysis (HOPP) is an autosomal dominant disorder characterized by episodic attacks of muscle weakness with concomitant hypokalemia (
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Mycelial Propagation and Molecular Phylogenetic Relationships of Commercially Cultivated Agrocybe cylindracea based on ITS Sequences and RAPD

Alam N, Kim JH, Shim MJ, Lee UY, Lee TS

  • KMID: 2312572
  • Mycobiology.
  • 2010 Jun;38(2):89-96.
This study evaluated the optimal vegetative growth conditions and molecular phylogenetic relationships of eleven strains of Agrocybe cylindracea collected from different ecological regions of Korea, China and Taiwan. The optimal...
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Cultural Conditions for Mycelial Growth and Molecular Phylogenetic Relationship in Different Wild Strains of Schizophyllum commune

Alam N, Cha YJ, Shim MJ, Lee TS, Lee UY

  • KMID: 2312559
  • Mycobiology.
  • 2010 Mar;38(1):17-25.
The common split-gilled mushroom, Schizophyllum commune is found throughout the world on woody plants. This study was initiated to evaluate conditions for favorable vegetative growth and to determine molecular phylogenetic...
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