J Adv Prosthodont.  2014 Dec;6(6):539-546. 10.4047/jap.2014.6.6.539.

Comparable efficacy of silk fibroin with the collagen membranes for guided bone regeneration in rat calvarial defects

Affiliations
  • 1Department of Oral and Maxillofacial Surgery, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.
  • 2Department of Prosthodontics, Hallym University School of Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea. hyewonshim@hallym.or.kr
  • 3Department of Emergency Medicine, Konkuk University School of medicine, Konkuk University Medical Center, Seoul, Republic of Korea.

Abstract

PURPOSE
Silk fibroin (SF) is a new degradable barrier membrane for guided bone regeneration (GBR) that can reduce the risk of pathogen transmission and the high costs associated with the use of collagen membranes. This study compared the efficacy of SF membranes on GBR with collagen membranes (Bio-Gide(R)) using a rat calvarial defect model.
MATERIALS AND METHODS
Thirty-six male Sprague Dawley rats with two 5 mm-sized circular defects in the calvarial bone were prepared (n=72). The study groups were divided into a control group (no membrane) and two experimental groups (SF membrane and Bio-Gide(R)). Each group of 24 samples was subdivided at 2, 4, and 8 weeks after implantation. New bone formation was evaluated using microcomputerized tomography and histological examination.
RESULTS
Bone regeneration was observed in the SF and Bio-Gide(R)-treated groups to a greater extent than in the control group (mean volume of new bone was 5.49 +/- 1.48 mm3 at 8 weeks). There were different patterns of bone regeneration between the SF membrane and the Bio-Gide(R) samples. However, the absolute volume of new bone in the SF membrane-treated group was not significantly different from that in the collagen membrane-treated group at 8 weeks (8.75 +/- 0.80 vs. 8.47 +/- 0.75 mm3, respectively, P=.592).
CONCLUSION
SF membranes successfully enhanced comparable volumes of bone regeneration in calvarial bone defects compared with collagen membranes. Considering the lower cost and lesser risk of infectious transmission from animal tissue, SF membranes are a viable alternative to collagen membranes for GBR.

Keyword

Silk; Bone regeneration; Membranes; Dental implants; Collagen; Guided tissue regeneration

MeSH Terms

Animals
Bone Regeneration*
Collagen*
Dental Implants
Disease Transmission, Infectious
Fibroins*
Guided Tissue Regeneration
Humans
Male
Membranes*
Microcomputers
Osteogenesis
Rats*
Rats, Sprague-Dawley
Silk*
Collagen
Dental Implants
Fibroins
Silk
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