Korean J Prev Med.  1988 Nov;21(2):295-306.

Dose-Response Relationship between Catalase and Superoxide dismutase Activity in Testes of Acutely Intoxicated Rats by Cadmium

• Park BY
• Park JD
• Chung KC

Abstract

Dose-response relationship among blood cadmium concentrations, catalase and superoxide dismutase activities were studied with acutely intoxicated rats by cadmium. The Sprague-Dawley male rats to which single dose of 1-32 mg/kg CdCl2 were administered into peritoneal cavity were sacrificed by decapitation at 3-36 hours after the administration. Cadmium concentrations in blood increased significantly with dose of CdCl2 administered and reached peak level at 3 hours later. Catalase activities in rats' tests were not correlated with exposure time elapsed after the administration in rats to which 1-2 mg/kg of CdCl2 were administered, but they showed linear relationship with time in groups to which 4-32 mg/kg of CdCl2 were administered. Cu, Zn-SOD activities in tests of acutely intoxicated rats by cadmium were not altered either by dosage or by time elapsed after the administration. Mn-SOD activities in the tests were also not influenced by dosage of 1-2 mg/kg CdCl2, but remarkably inactivated by dosage of 4-32 mg/kg CdCl2 with time elapsed after the administration. Neither catalase, Cu, Zn-SOD nor Mn-SOD activities of tests were correlated with blood cadmium concentrations in acutely intoxicated rats by cadmium.

MeSH Terms

Animals
Cadmium Chloride
Cadmium*
Catalase*
Decapitation
Humans
Male
Peritoneal Cavity
Rats*
Rats, Sprague-Dawley
Superoxide Dismutase*
Superoxides*
Testis*
Cadmium
Cadmium Chloride
Catalase
Superoxide Dismutase
Superoxides