Diabetes Metab J.  2011 Dec;35(6):610-618. 10.4093/dmj.2011.35.6.610.

Associations between Fatness, Fitness, IGF and IMT among Obese Korean Male Adolescents

• Kim ES
• Park JH
• Lee MK
• Lee DH
• Kang ES
• Lee HC
• Jekal Y
• Jeon JY

• KMID: 2280729
• DOI: http://doi.org/10.4093/dmj.2011.35.6.610

Abstract

BACKGROUND
The purpose of this study was to investigate the association between obesity, fitness levels and cardiovascular (CVD) risk factors, and to identify the correlation between of insulin-like growth factor (IGF)-1, IGF binding protein-3 (IGFBP-3), and carotid intima media thickness (IMT) in Korean adolescents.
METHODS
A total of 225 high school males with a mean age of 16.96+/-0.23 years participated in this study, and their fatness and fitness levels, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), blood lipids, IGF-1, IGFBP-3, and IMT were measured.
RESULTS
The results showed that total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), fasting insulin, HOMA-IR, IGF-1, and IGFBP-3 levels were significantly higher in the most obese group than in the other two groups (tertiles). Muscular and cardiopulmonary fitness were negatively associated with weight, body mass index (BMI), fat mass, body fat, waist circumference (WC), fasting insulin, HOMA-IR, and IMT. IGF-1 and IGFBP-3 levels were correlated with WC, hip circumference (HC), fasting glucose, TG, HDL-C, fasting insulin, and HOMA-IR. IMT levels were significantly associated with weight, BMI, muscle mass, fat mass, percent body fat, WC, HC, systolic blood pressure, diastolic blood pressure and high-sensitivity C-reactive protein.
CONCLUSION
There was a significant association between increased obesity and decreased fitness and HOMA-IR, IGF, and IMT among adolescents.

Keyword

Adolescent; Insulin-like growth factor 1; Insulin resistance; Intima media thickness; Obesity

MeSH Terms

Adipose Tissue
Adolescent
Blood Pressure
Body Weight
Carotid Intima-Media Thickness
Cholesterol
Cholesterol, HDL
Fasting
Glucose
Hip
Homeostasis
Humans
Insulin
Insulin Resistance
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Lipoproteins
Male
Muscles
Obesity
Risk Factors
Waist Circumference
Surveys and Questionnaires
Cholesterol
Cholesterol, HDL
Glucose
Insulin
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Lipoproteins

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