Ann Pediatr Endocrinol Metab.  2024 Aug;29(4):258-265. 10.6065/apem.2346158.079.

Correlation of tri-ponderal mass index with insulin-like growth factor-I and insulin-like growth factor binding protein-3 in children and adolescents

• Choi IH
• Kim SY
• Kim M

• KMID: 2559454
• DOI: http://doi.org/10.6065/apem.2346158.079

Abstract

Purpose
We aimed to investigate the relationship between the tri-ponderal mass index (TMI), a new indirect measure of fat mass, and insulin-like growth factor (IGF)-I/IGF binding protein (IGFBP)-3.
Methods
The study included 1,630 children and adolescents who visited Jeonbuk National University Children's Hospital. Each patient’s medical record was retrospectively reviewed for age, sex, height, weight, body mass index (BMI), TMI, and IGF-1 and IGFBP-3 levels. Study participants were divided by sex and then categorized by age, BMI, and TMI. Finally, the correlations of TMI with IGF-1 level, IGF-1 standard deviation score (SDS), IGFBP-3 level, IGFBP-3 SDS, and IGF-1/IGFBP-3 ratio were investigated.
Results
All participants were <19 years of age. BMI correlated with IGF-1 and IGFBP-3 levels in both sexes; however, the relationship with TMI differed by sex. TMI correlated with IGF-1 and IGFBP-3 SDS in boys and with IGF-1, IGFBP-3, and IGFBP-3 SDS in girls across all ages. In boys, BMI and TMI significantly correlated with IGF-1, IGF-1 SDS, IGFBP-3, IGFBP-3 SDS, and the IGF-1/IGFBP-3 ratio in the normal-weight group. TMI also correlated with IGF-1, IGFBP-3, and IGFBP-3 SDS in the overweight group. In girls, BMI significantly correlated with IGF-1, IGF-1 SDS, IGFBP-3, IGFBP-3 SDS, and the IGF-1/IGFBP-3 ratio in the normal-weight group and with IGFBP-3 and IGFBP-3 SDS in the overweight group, while TMI correlated with IGF-1, IGF-1 SDS, and the IGF-1/IGFBP-3 ratio in the normal-weight group; with IGF-1, IGFBP-3, and IGFBP-3 SDS in the overweight group; and with IGFBP-3 SDS in the obese group.
Conclusion
TMI may more strongly correlate with IGFBP-3 level than BMI in overweight boys and with IGFBP-3 SDS in overweight and obese girls. The correlation of IGFBP-3 SDS with TMI may be helpful for evaluating weight status in adolescent girls.

Keyword

Tri-ponderal mass index; Body mass index; Insulin-like growth factor-1; Insulin-like growth factor binding protein-3

Reference

References

1. Di Cesare M, Sorić M, Bovet P, Miranda JJ, Bhutta Z, Stevens GA, et al. The epidemiological burden of obesity in childhood: a worldwide epidemic requiring urgent action. BMC Med. 2019; 25:212.

2. Kang S, Seo MY, Kim SH, Park MJ. Changes in lifestyle and obesity during the COVID-19 pandemic in Korean adolescents: based on the Korea Youth Risk Behavior Survey 2019 and 2020. Ann Pediatr Endocrinol Metab. 2022; 27:281–8.

3. Gwag SH, Oh YR, Ha JW, Kang E, Nam HK, Lee Y, et al. Weight changes of children in 1 year during COVID-19 pandemic. J Pediatr Endocrinol Metab. 2022; 35:297–302.

4. Park HK, Lim JS. Change of obesity prevalence and lifestyle patterns before and during COVID-19 among Korean adolescents. Ann Pediatr Endocrinol Metab. 2022; 27:183–91.

5. Kang HM, Jeong DC, Suh BK, Ahn MB. The impact of the coronavirus disease-2019 pandemic on childhood obesity and vitamin D status. J Korean Med Sci. 2021; 36:e21.

6. Cole TJ. Weight-stature indices to measure underweight, overweight, and obesity. In: Himes JE, editor. Anthropometric assessment of nutritional status. New York: Wiley-Liss; 1991:83-111.

7. Dietz WH, Bellizzi MC. Introduction: the use of body mass index to assess obesity in children. Am J Clin Nutr. 1999; 70:123S–125S.

8. O’Connor EA, Evans CV, Burda BU, Walsh ES, Eder M, Lozano P. Screening for obesity and intervention for weight management in children and adolescents: evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2017; 317:2427–44.

9. Cole TJ. Weight/height p compared to weight/height2 for assessing adiposity in childhood: influence of age and bone age on p during puberty. Ann Hum Biol. 1986; 13:433–51.

10. Burton RF. Why is the body mass index calculated as mass/height2, not as mass/height3? Ann Hum Biol. 2007; 34:656–63.

11. Heymsfield SB, Heo M, Thomas D, Pietrobelli A. Scaling of body composition to height: relevance to height-normalized indexes. Am J Clin Nutr. 2011; 93:736–40.

12. Peterson CM, Su H, Thomas DM, Heo M, Golnabi AH, Pietrobelli A, et al. Tri-ponderal mass index vs body mass index in estimating body fat during adolescence. JAMA Pediatr. 2017; 171:629–36.

13. De Lorenzo A, Romano L, Di Renzo L, Gualtieri P, Salimei C, Carrano E, et al. Triponderal mass index rather than body mass index: An indicator of high adiposity in Italian children and adolescents. Nutrition. 2019; 60:41–7.

14. Wang X, Dong B, Ma J, Song Y, Zou Z, Arnold L, et al. Role of tri-ponderal mass index in cardio-metabolic risk assessment in children and adolescents: compared with body mass index. Int J Obes (Lond). 2020; 44:886–94.

15. Malavazos AE, Capitanio G, Milani V, Ambrogi F, Matelloni IA, Basilico S, et al. Tri-ponderal mass index vs body mass index in discriminating central obesity and hypertension in adolescents with overweight. Nutr Metab Cardiovasc Dis. 2021; 31:1613–21.

16. Park HK, Shim YS. Distribution of tri-ponderal mass index and its Relation to body mass index in children and adolescents aged 10 to 20 Years. J Clin Endocrinol Metab. 2020; 105:e826–34.

17. Shim YS. The relationship between tri-ponderal mass index and metabolic syndrome and its components in youth aged 10-20 Years. Sci Rep. 2019; 9:14462.

18. Al-Samerria S, Radovick S. The role of insulin-like growth factor-1 (IGF-1) in the control of neuroendocrine regulation of growth. Cells. 2021; 10:2664.

19. Scavo LM, Karas M, Murray M, Leroith D. Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes. J Clin Endocrinol Metab. 2004; 89:3543–53.

20. Blüher S, Kratzsch J, Kiess W. Insulin-like growth factor I, growth hormone and insulin in white adipose tissue. Best Pract Res Clin Endocrinol Metab. 2005; 19:577–87.

21. Boucher J, Softic S, Ouaamari A, Krumpoch M, Kleinridders A, Kulkarni RN, et al. Differential roles of insulin and IGF-1 receptors in adipose tissue development and function. Diabetes. 2016; 65:2201–13.

22. Aguirre GA, Ita J, Garza R, Castilla-Cortazar I. Insulin-like growth factor-1 deficiency and metabolic syndrome. J Transl Med. 2016; 14:3.

23. Katz L, Gralewski K, Abrams P, Brar P, Gallagher P, Lipman T, et al. Insulin-like growth factor-I and insulin-like growth factor binding protein-1 are related to cardiovascular disease biomarkers in obese adolescents. Pediatr Diabetes. 2016; 17:77–86.

24. Takahashi Y. The role of growth hormone and insulin-like growth factor-I in the liver. Int J Moi Sci. 2017; 18:1447.

25. Haywood N, Slater T, Mattews C, Wheatcrotf S. Ther insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes. Mol Metab. 2019; 19:86–96.

26. Kim HS. Role of insulin-like growth factor binding protein-3 in glucose and lipid metabolism. Ann Pediatr Endocrinol Metab. 2013; 18:9–12.

27. Kim JH, Yun S, Hwang SS, SHIM JO, Chae HW, Lee YJ, et al. The 2017 Korean National Growth Charts for children and adolescents: development, improvement, and prospects. Korean J Pediatr. 2018; 61:135–49.

28. Cole TJ. The LMS method for constructing mormalized growth standards. Eur J Clin Nutr. 1990; 44:45–60.

29. Hyun SE, Lee BC, Suh BK, Chung SC, Ko CW, Kim HS, et al. Reference values for serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in Korean children and adolescents. Clin Biochem. 2012; 45:16–21.

30. Savastano S, Di Somma C, Pizza G, De Rosa A, Nedi V, Rossi A, et al. Liver-spleen axis, insulin-like growth factor-(IGF)-I axis and fat mass in overweight/obese females. J Transl Med. 2011; 9:136.

31. Touskova V, Trachta P, Kavalkova P, Drapalova J, Haluzikova D, Mraz M, et al. Serum concentrations and tissue expression of components of insulin-like growth factoraxis in females with type 2 diabetes mellitus and obesity: the influence of very-low-calorie diet. Mol Cell Endocrinol. 2012; 361:172–8.

32. Sirbu A, Gologan S, Arbanas T, Copaescu C, Martin S, Albu A, et al. Adiponectin, body mass index and hepatic steatosis are independently associated with IGF-I status in obese non-diabetic women. Growth Horm IGF Res. 2013; 23:2–7.

33. Kanazawa I, Yamaguchi T, Sugimoto T. Serum insulin-like growth factor-I is negatively associated with serum adiponectin in type 2 diabetes mellitus. Growth Horm IGF Res. 2011; 21:268–71.

34. Van Sickle BJ, Simmons J, Hall R, Raines M, Ness K. Increased circulating IL-8 is associated with reduced IGF-I and related to poor metabolic control in adolescents with type 1 diabetes mellitus. Cytokine. 2009; 48:290–4.

35. Jones JI, Clemmons DR. Insulin-like growth factor and their binding proteins: biological actions. Endocr Rev. 1995; 16:3–34.

36. Gaunt TR, Cooper JA, Miller GJ, Day IN. Positive associations between single nucleotide polymorphisms in the IGF-2 gene region and body mass index in adult males. Hum Mol Genet. 2001; 10:1491–501.

37. Kim HS, Ali O, Shim M, Lee KH, Vuguin P, Muzumdar R, et al. Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo. Pediatr Res. 2007; 61:159–64.

38. Maridas DE, DeMambro VE, Le PT, Mohan S, Rosen CJ. IGFBP4 is required for adipogenesis and influences the distribution of adipose depots. Endocrinolog y. 2017; 158:3488–500.

39. Kempf E, Landgraf K, Vogel T, Spielau U, Stein R, Raschpichler M, et al. Associations of GHR, IGF-1 and IGFBP-3 expression in adipose tissue cells with obesity-related alterations in corresponding circulating levels and adipose tissue function in children. Adipocyte. 2022; 11:630–42.

40. Ben Ounis O, Elloumi M, Zouhal H, Makni E, Denguezli M, Amri M, et al. Effect of individualized exercise training combined with diet restriction on inflammatory markers and IGF-1/IGFBP-3 in obese children. Ann Nutr Metab. 2010; 56:260–6.