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Effects of the Combination of Evogliptin and Leucine on Insulin Resistance and Hepatic Steatosis in High-Fat Diet-Fed Mice

Shin CY, Lee HY, Kim GH, Park SY, Choi WS, Sohn UD

In this study, we aimed to investigate the effects of 8 weeks of treatment with a combination of evogliptin and leucine, a branchedchain amino acid, in mice with high-fat diet...
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The Shape of the Oral Glucose Tolerance Test-Glucose Response Curve in Islet Cell Antibody-Positive vs. -Negative Obese Youth Clinically Diagnosed with Type 2 Diabetes

Kim JY, Tfayli H, Bacha F, Arslanian S

Background: The oral glucose tolerance test (OGTT)-glucose response curves (GRCs; incessant increase, monophasic, and biphasic) reflect insulin sensitivity and β-cell function, being worse in the former and superior in the...
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The association of dietary patterns with insulin resistance in Korean adults: based on the 2015 Korea National Health and Nutrition Examination Survey

Kim IS, Yang YJ

Purpose: This study was conducted to identify the association between insulin resistance and the major dietary patterns of Korean adults. Methods: This study used data from the 2015 Korea National Health...
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Morin alleviates fructose-induced metabolic syndrome in rats via ameliorating oxidative stress, inflammatory and fibrotic markers

Heeba GH, Rabie EM, Abuzeid MM, Bekhit AA, Khalifa MM

Metabolic syndrome (MBS) is a widespread disease that has strongly related to unhealthy diet and low physical activity, which initiate more serious conditions such as obesity, cardiovascular diseases and type...
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Can antioxidants be effective therapeutics for type 2 diabetes?

Park S, Park SY

The global obesity epidemic and the growing elderly population largely contribute to the increasing incidence of type 2 diabetes. Insulin resistance acts as a critical link between the present obesity...
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Prednisolone-induced diabetes mellitus without pancreatic islet pathology in a dog

Yun T, Kim H, Koo Y, Chang D, Kang BT, Yang MP

A one-year-old, intact male Maltese was referred with dehydration, anorexia, and marked hyperglycemia. The dog had been managed due to meningoencephalitis of unknown etiology (MUE) for three months. The dog...
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Role of obesity-induced inflammation in the development of insulin resistance and type 2 diabetes: history of the research and remaining questions

Kim J, Lee J

The prevalence of obesity has increased alarmingly both worldwide and in Korea. This has also dramatically increased the prevalence of chronic obesity-associated diseases, including type 2 diabetes (T2D). Extensive studies...
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Dairy consumption and risk of type-2 diabetes: the untold story

Gudi SK

The role of dairy products in human health has been extensively studied for decades; however, evidence regarding dairy consumption and risk of type 2 diabetes (T2D) remains controversial and uncertain....
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Umbilical Cord-Mesenchymal Stem Cell-Conditioned Medium Improves Insulin Resistance in C2C12 Cell

Kim KS, Choi YK, Kim MJ, Hwang JW, Min K, Jung SY, Kim SK, Choi YS, Cho YW

Background Umbilical cord-mesenchymal stem cell-conditioned medium (UC-MSC-CM) has emerged as a promising cell-free therapy. The aim of this study was to explore the therapeutic effects of UC-MSC-CM on insulin resistance in...
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Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey

Ha J, Lee J, Lim DJ, Lee JM, Chang SA, Kang MI, Kim MH

Background/Aims: Thyroid hormones are involved in wide range of glucose metabolism functions. Overt thyroid dysfunctions are related to altered glucose homeostasis. However, it is not conclusive as to whether subtle...
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Insulin Resistance Increases Serum Immunoglobulin E Sensitization in Premenopausal Women

Lee SE, Baek JY, Han K, Koh EH

Background Although studies have shown that obesity is associated with aeroallergen sensitization (atopy), controversy still exists. We aimed to investigate the association between metabolic status, obesity, and atopy stratified by sex...
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Changes in Liver Enzymes and Metabolic Profile in Adolescents with Fatty Liver following Exercise Interventions

Iraji H, Minasian V, Kelishadi R

Purpose: Nonalcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver diseases in both adults and children with obesity. The aim of this study was to compare...
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Vimentin Deficiency Prevents High-Fat Diet-Induced Obesity and Insulin Resistance in Mice

Kim S, Kim I, Cho W, Oh GT, Park YM

Background Obesity and type 2 diabetes mellitus are world-wide health problems, and lack of understanding of their linking mechanism is one reason for limited treatment options. We determined if genetic deletion...
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Early menarche and its consequence in Korean female: reducing fructose intake could be one solution

Kim JH, Lim JS

The mean age at menarche (AAM) of Korean females has been rapidly decreasing over the last 50 years; currently, the prevalence of early menarche (
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Serum Transferrin Predicts New-Onset Type 2 Diabetes in Koreans: A 4-Year Retrospective Longitudinal Study

Kim JD, Lim DM, Park KY, Park SE, Rhee EJ, Park CY, Lee WY, Oh KW

Background: It is well known that high serum ferritin, a marker of iron storage, predicts incident type 2 diabetes. Limited information is available on the association between transferrin, another marker...
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Metabolically Healthy and Unhealthy Normal Weight and Obesity

Stefan N

Increased fat mass is an established risk factor for the cardiometabolic diseases type 2 diabetes and cardiovascular disease (CVD) and is associated with increased risk of all-cause and CVD mortality....
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Chicken consumption and insulin resistance in non-diabetic older adults

Yeum KJ, Kim YS, Joo NS

Purpose: Histidine-containing dipeptides, which are rich in chicken, have been reported to reduce the risk of metabolic abnormalities via anticarbonylation mechanism in animal models. To determine the effect of dietary...
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Glucose Metabolism in Pregnant Women with Normal Glucose Tolerance

Koo BK

Insulin resistance increases from conception into late pregnancy in women with normal glucose tolerance as well as women with gestational diabetes. Increasing insulin resistance during pregnancy permits adequate supply of...
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Insight into the pathogensis of polycystic ovarian syndrome

Jung YW, Lee GH, Han YJ, Cha DH

Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women, which is characterized by the oligo/ anovulation, hyperandrogenism (HA) and polycystic ovarian morphology which are diagnostic criteria. PCOS...
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Association between Breakfast Skipping and Homeostasis Model Assessment of Insulin Resistance and the Atherosclerotic Cardiovascular Disease Risk in Non-Diabetic Korean Adults Aged 40–79 Years

Lee H, Kang Y, Yoon K, Song Y, Shim JY

Background: It is reported that the decline in breakfast consumption is associated with diabetes, metabolic disease, and cardiovascular disease. This study analyzed the association between skipping breakfast and the homeostasis...
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