Korean J Pediatr Infect Dis.  2011 Dec;18(2):182-192.

The Influence of Atopic Findings on Severity of Pneumonia in Children with 2009 Pandemic Influenza A (H1N1) Infection

• Kim JH
• Kim HJ
• Kang IJ

Abstract

PURPOSE
Atopic findings may be associated with severity of pneumonia in 2009 pandemic influenza A (H1N1) infection, which could suggest a possible association between atopic findings and the severity of viral infections. Thus, we studied association between atopic findings and severity of disease in children with H1N1 influenza infection.
METHODS
A retrospective study was performed in 74 children admitted in a single tertiary institute and confirmed as H1N1 patients by reverse transcriptase (RT) - polymerase chain reaction (PCR). They were divided into 2 groups according to the severity of pneumonia. We evaluated whether the atopic finding is risk factor between the two groups.
RESULTS
Children with severe pneumonia had higher percentages of serum eosinophilia (88% vs 40%, P<0.001), asthma (65% vs 35%, P=0.011), allergic rhinitis (71% vs 40%, P=0.009), and IgE level (P=0.007). We found positive correlations between aeroallergen sensitizations and severity of pneumonia (82% vs 53%, P=0.007).
CONCLUSION
Among patients with H1N1 pneumonia, asthma and atopic findings are risk factors for severity of pneumonia.

Keyword

2009 Pandemic influenza A (H1N1); Pneumonia; Atopy; Allergic disease

MeSH Terms

Asthma
Child
Eosinophilia
Humans
Immunoglobulin E
Influenza, Human
Pandemics
Pneumonia
Polymerase Chain Reaction
Retrospective Studies
Rhinitis
Rhinitis, Allergic, Perennial
Risk Factors
RNA-Directed DNA Polymerase
Immunoglobulin E
RNA-Directed DNA Polymerase

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