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Analysis of the Conjunctival Microbiome in Patients with Atopic Keratoconjunctivitis and Healthy Individuals

Hur MS, Lee JS, Jang M, Shin HJ, Lee YW

Background: Atopic dermatitis (AD) has been clarified that imbalance of bacterial and fungal communities in the skin and gut play key roles in immunologic dysfunction. Atopic keratoconjunctivitis (AKC), one of...
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Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population

Kim BK, Song WJ, Seo B, Kim JY, Kim SH, Jang HC, Kim KW, Chang YS

Background/Aims: Recent evidence suggests an association between allergic sensitization and metabolic markers. However, this association has rarely been examined in the elderly. Retinol-binding protein-4 (RBP-4) is a recently identified adipokine...
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Inverse Relationship between Adenoid Size and Asthma or Atopy in Children: A Preliminary Study

Noh Y, Choi JE, Lee KE, Chung SK, Hong SD, Kim HY

Background and Objectives One of the most common surgical procedures in children is adenoidectomy, but the causes of adenoid hypertrophy are not fully understood. Some studies have found that allergies...
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FFA2 Activation Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice

Kang J, Im DS

Gut microbiota produce dietary metabolites such as short-chain fatty acids, which exhibit anti-inflammatory effects. Free fatty acid receptor 2 (FFA2, formerly known as GPR43) is a specific receptor for short-chain...
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Topical Application of S1P2 Antagonist JTE-013 Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice

Kang J, Lee JH, Im DS

Sphingosine-1-phosphate (S1P) and its receptors have been implicated in atopic dermatitis. S1P2 was found to function as a proallergic receptor, while its antagonist JTE-013 was found to suppress allergic asthma...
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Usefulness of bronchodilator response as an index of asthma control in children

Kim JD, Kim SY, Kim YH, Kim KW, Sohn MH, Sol IS

PURPOSE: Assessing asthma control is important for proper management, and various indices for objective assessment of asthma control, such as fractional exhaled nitric oxide (FeNO) and asthma control test (ACT)...
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Evaluation of multiple allergen simultaneous (sIgE) testing compared to intradermal testing in the etiological diagnosis of atopic dermatitis in horses

Wilkołek , Szczepanik M, Sitkowski , Rodzik B, Pluta M, Taszkun I, Gołyński M

Although intradermal testing (IDT) is commonly used in the etiological diagnosis of allergies, in vitro testing for specific IgE (sIgE) is an attractive alternative. Currently, new laboratory techniques in veterinary...
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The Incidence of Delayed-Type Hypersensitivity Reactions to Apples Among Patients Allergic to Birch Pollen

Wagner A, Zielińska-Bliźniewska H, Wagner W

The major apple allergen Mal d 1 cross-reacts with the homologous birch pollen allergen Bet v 1 and causes immunoglobulin E (IgE)-mediated immediate-type allergic reactions. In some patients, delayed-type hypersensitivity...
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Analysis of Medical Treatment Interest Trend in Rural Environment by Big Data

Hwang SW

BACKGROUND: In the rural environment, medicine treatment has analyzed the health behavior of some rural areas, but it is necessary to study and generalize trends of interest in the whole...
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Trends in the Prevalence of Childhood Asthma in Seoul Metropolitan City, Korea: The Seoul Atopy ∙ Asthma-friendly School Project

Cho YM, Kim CB, Yeon KN, Lee ES, Kim K

OBJECTIVES: The project Seoul Atopy ∙ Asthma-friendly School investigated the current status of childhood asthma to enable formulation of a preventative policy. We evaluated the current prevalence of childhood asthma...
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A clinician's reference guide for the management of atopic dermatitis in Asians

Chow S, Seow CS, Dizon MV, Godse K, Foong H, Chan V, Khang TH, Xiang L, Hidayat S, Listiawan , Triwahyudi D, Gondokaryono SP, Sutedja E, Diana IA, Suwarsa O, Dharmadji , Siswati AS, Danarti R, Soebaryo R, Budianti W, for the Asian Academy of Dermatology & Venereology

BACKGROUND: Atopic dermatitis (AD) is a common skin condition among Asians. Recent studies have shown that Asian AD has a unique clinical and immunologic phenotype compared with European/American AD. OBJECTIVE: The...
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Reference Values and Utility of Serum Total Immunoglobulin E for Predicting Atopy and Allergic Diseases in Korean Schoolchildren

Kim HY, Choi J, Ahn K, Hahm MI, Lee SY, Kim WK, Chae Y, Park YM, Han MY, Lee KJ, Kwon HJ, Kim S, Yoo H, Kim J

The present study aimed to investigate the distribution of total serum immunoglobulin E (IgE) levels in Korean schoolchildren and to evaluate its utility in the prediction of atopy and allergic...
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Dietary primary prevention of allergic diseases in children: the Philippine guidelines

Recto MS, Genuino ML, Castor MA, Casis-Hao , Tamondong-Lachica DR, Sales MI, Tan MG, Mondonedo , Dionisio-Capulong RC, The PSAAI and the PSPGHAN

Allergic diseases, such as asthma, allergic rhinitis, eczema, and food allergy, are preventable diseases. Primary prevention strategies of allergic diseases have been in scrutiny. Effective prevention strategies maybe started prenatally,...
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Relationship between atopy and bronchial hyperresponsiveness to indirect stimuli in asthmatic children

Park TY, Yi MJ, Choi WH, Kim SY, Yu R, Ban JE, Yang S, Hwang IT, Baek HS

PURPOSE: Both atopy and bronchial hyperresponsiveness (BHR) are characteristic features of asthma. Several BHR studies comparing groups of atopic and nonatopic asthmatics have reported conflicting results. The aim of this...
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Genes Involved in Interleukin-1 Receptor Type II Activities Are Associated With Asthmatic Phenotypes

Madore AM, Vaillancourt VT, Bouzigon E, Sarnowski , Monier F, Dizier MH, Demenais F, Laprise C

PURPOSE: Interleukin-1 (IL-1) plays a key role in inflammation and immunity and its decoy receptor, IL-1R2, has been implicated in transcriptomic and genetic studies of asthma. METHODS: Two large asthma family...
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Role of eosinophilic inflammation and atopy in elderly asthmatic patients

Kawamatawong T, Siripongpun S, Rerkpattanapipat T

BACKGROUND: Asthma in the elderly is severe and associated with poor treatment outcome. Although atopy has an important role in pathogenesis, its role in the elderly is unclear, partly due...
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Distinct Inflammatory Profiles in Atopic and Nonatopic Patients With Chronic Rhinosinustis Accompanied by Nasal Polyps in Western China

Ba L, Du J, Liu F, Yang F, Han M, Liu S, Lin P, Li H

PURPOSE: The role of systemic sensitization in the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP) remains elusive. This study sought to characterize the pattern of cytokines in polyp tissues...
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The Association of Lung Function, Bronchial Hyperresponsiveness, and Exhaled Nitric Oxide Differs Between Atopic and Non-atopic Asthma in Children

Shim E, Lee E, Yang SI, Jung YH, Park GM, Kim HY, Seo JH, Yu J

PURPOSE: Although many previous studies have attempted to identify differences between atopic asthma (AA) and non-atopic asthma (NAA), they have mainly focused on the difference of each variable of lung...
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Serial Changes in Serum Eosinophil-associated Mediators between Atopic and Non-atopic Children after Mycoplasma pneumoniae pneumonia

Kim JH, Cho TS, Moon JH, Kim CR, Oh JW

PURPOSE: Mycoplasma pneumoniae pneumonia (MP) is associated with the exacerbation, timing, and onset of asthma. The goal of this study was to elucidate the impact of MP on eosinophil-related hyper-reactive...
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Intestinal Microflora and Atopy Development in Infants during the First Nine Months

Kim JS, Sung TJ, Park HK, Park JY, Cho HC, Hwang IT, Lee HR

BACKGROUND: The intestinal microflora varies according to the factors such as age, diet and environment. It is debated whether the changes of microbiota after birth are associated with atopic disease....
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