Ann Dermatol.  2010 May;22(2):206-208. 10.5021/ad.2010.22.2.206.

Atypical Porokeratosis Developing Following Bone Marrow Transplantation in a Patient with Myelodysplastic Syndrome

Affiliations
  • 1Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea. derm@catholic.ac.kr

Abstract

Porokeratosis is an abnormal disease of keratinization of epidermis. It is clinically characterized by margins covered with keratin layer and it typically has an atrophied macule with a protruded, circular form. Histopathologically, it shows the findings of cornoid lamella. Risk factors for its development include organ transplantation, long-term use of corticosteroids, immunocompromised status, including AIDS, and exposure to ultraviolet light. We herein report a case of atypical porokeratosis in a 38-year-old man who developed porokeratosis involving multiple sites following bone marrow transplantation for myelodysplastic syndrome.

Keyword

Bone marrow transplantation; Myelodysplastic syndrome; Porokeratosis

MeSH Terms

Adrenal Cortex Hormones
Adult
Bone Marrow
Bone Marrow Transplantation
Epidermis
Humans
Keratins
Myelodysplastic Syndromes
Organ Transplantation
Porokeratosis
Risk Factors
Transplants
Ultraviolet Rays
Adrenal Cortex Hormones
Keratins

Figure

  • Fig. 1 (A) Asymptomatic, multiple, slowly spreading, 0.5~2.5 cm, brownish to erythematous papules and plaques widely distributed on the body for 8 years. (B) Erythematous plaque with central atrophy and peripheral ridge. (C) Lesion was followed clinically without specific therapy for 6 months.

  • Fig. 2 Typical cornoid lamella characteristic of porokeratosis (H&E, ×100).


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