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Korean J Hematol.  2006 Sep;41(3):204-207. 10.5045/kjh.2006.41.3.204.

Evans Syndrome following T Cell-repleted Unrelated Bone Marrow Transplantation for Myelodysplastic Syndrome: Successful Response to High-dose Corticosteroid

Affiliations
  • 1Department of Pediatrics, Hanyang University Medical Center, Seoul, Korea. cord@hanyang.ac.kr
  • 2Inje University Paik Hospital, Seoul, Korea.
  • 3Dong-A University Medical Center, Busan, Korea.

Abstract

Evans syndrome after hematopoietic stem cell transplantation rarely occurs and this condition is refractory to treatment, particularly in childhood. We experienced a case of Evans syndrome following unmanipulated unrelated bone marrow transplantation. Evans syndrome developed at early post-transplantation period (day +42) and it responded very well to high-dose corticosteroid. Autoimmune cytopenia should be considered for post-engraftment cytopenias and high-dose corticosteroid therapy might be considered as a treatment of the early onset type of autoimmune cytopenia that can occur after hematopoietic stem cell transplantation.

Keyword

Evans syndrome; T cell repleted bone marrow transplantation; High-dose corticosteroid

MeSH Terms

Bone Marrow Transplantation*
Bone Marrow*
Hematopoietic Stem Cell Transplantation
Myelodysplastic Syndromes*
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