Clin Pediatr Hematol Oncol.  2007 Apr;14(1):68-72.

Unrelated Cord Blood Transplantation Using Non-TBI Conditioning Regimen in a Child with Fanconi Anemia

• Park SS
• Park JA
• Lim YT

Abstract

Fanconi anemia is an autosomal recessive disorder characterized by progressive bone marrow failure, growth retardation, abnormal skin pigmentation, developmental anomalies and marked predisposition to myelodysplastic syndrome or acute myeloid leukemia. Allogeneic hematopoietic stem cell transplantation offers the only curative treatment for bone marrow complications of these patients. Recently umbilical cord blood transplantation has been tried as a successful alternative to bone marrow transplantation in patients with Fanconi anemia, but the results are somewhat disappointing yet. In this report, we describe a case of unrelated HLA 1 antigen mismatched cord blood transplantation using non-TBI conditioning regimen in a 6-year-old boy with Fanconi anemia who is alive with a perfect performance status and normal blood count currently 17 months after the transplantation.

Keyword

Fanconi anemia; Unrelated cord blood transplantation

MeSH Terms

Bone Marrow
Bone Marrow Transplantation
Child*
Fanconi Anemia*
Fetal Blood*
Hematopoietic Stem Cell Transplantation
Humans
Leukemia, Myeloid, Acute
Male
Myelodysplastic Syndromes
Skin Pigmentation