Allergy Asthma Respir Dis.  2013 Sep;1(3):235-240. 10.4168/aard.2013.1.3.235.

Increased serum surfactant protein-D in the infants with acute respiratory syncytial virus bronchiolitis

• Chu MA
• Lee EJ
• Park HJ
• Lee KH
• Kim WT
• Chung HL

• KMID: 2262966
• DOI: http://doi.org/10.4168/aard.2013.1.3.235

Abstract

PURPOSE
Collectin family is an important component of innate immunity, of which surfactant protein (SP)-D and mannose-binding lectin (MBL) are the most characterized. We examined SP-D and MBL in young children with acute respiratory syncytial virus (RSV) bronchiolitis.
METHODS
Sixty-three children (< or =24 months of age) admitted with the first RSV bronchiolitis during 2 epidemics and followed for 1 year after discharge were enrolled. The patients were defined as severe group when they had 2 of followings during admission: hypoxemia (<92% oxygen saturation), rapid breathing (and/or lower chest wall indrawing), and >7 days of hospital stay. All children were evaluated if they had recurrent wheezing during follow-up. SP-D and MBL were measured using enzyme-linked immunosorbent assay in serum collected on admission and compared with controls. Their levels were evaluated in relation to the symptom severity during admission and recurrence of wheezing after discharge.
RESULTS
Serum SP-D increased significantly in the patients (P<0.01), but MBL showed no difference compared to the controls. SP-D levels were significantly higher in severe group compared with nonsevere group (P<0.05). SP-D levels in the patients with recurrent wheezing after discharge were significantly higher than in those without (P<0.05). MBL showed no difference in relation to the symptom severity or recurrence of wheezing.
CONCLUSION
Our study showed that serum SP-D was associated with the severity of RSV bronchiolitis and suggests that it might be a biomarker of lung injury and recurrence of wheezing illnesses in the young children admitted with their first RSV bronchiolitis.

Keyword

Surfactant protein-D; Mannose-binding lectin; Respiratory syncytial virus; Bronchiolitis

MeSH Terms

Anoxia
Bronchiolitis
Child
Collectins
Enzyme-Linked Immunosorbent Assay
Follow-Up Studies
Humans
Immunity, Innate
Infant
Length of Stay
Lung Injury
Mannose-Binding Lectin
Oxygen
Pulmonary Surfactant-Associated Protein D
Recurrence
Respiration
Respiratory Sounds
Respiratory Syncytial Viruses
Thoracic Wall
Collectins
Mannose-Binding Lectin
Oxygen
Pulmonary Surfactant-Associated Protein D

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