Korean J Asthma Allergy Clin Immunol.  2007 Dec;27(4):235-240.

ECP, RANTES, and Eotaxin in Respiratory Syncytial Virus Bronchiolitis: Relation to Subsequent Wheezing

Abstract

BACKGROUND: Infants with respiratory syncytial virus (RSV) bronchiolitis are at increased risk of developing persistent wheezing and bronchial asthma later in life. Eosinophil- related-inflammatory mechanisms play a role in RSV bronchiolitis and asthma.
OBJECTIVE
The aim of our study was to find a relationship between eosinophil cationic protein (ECP), RANTES, and eotaxin level in the nasophageal secretion of RSV bronchiolitis patients and subsequent wheezing. METHOD: ECP, RANTES, and eotaxin level in nasopharyngeal secretion were determined in 28 children hospitalized with RSV bronchiolitis. 24 children were followed for two years after the RSV bronchiolitis. RESULT: 12 out of 24 children experienced subsequent wheezing verified by their physicians. Children who had subsequent wheezing showed significantly higher level of ECP, RANTES, and eotaxin in the nasopharyngeal secretion than those who had not. There was a positive correlations between ECP and RANTES, ECP and eotaxin in RSV bronchiolitis patients.
CONCLUSION
Nasopharyngeal ECP, RANTES, eotaxin may be useful in predicting the development of persistent wheezing in children affected by RSV bronchiolitis.

MeSH Terms

Asthma
Bronchiolitis*
Chemokine CCL5*
Child
Eosinophil Cationic Protein
Humans
Infant
Respiratory Sounds*
Respiratory Syncytial Viruses*
Chemokine CCL5
Eosinophil Cationic Protein