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β-Carotene Inhibits Activation of NF-κB, Activator Protein-1, and STAT3 and Regulates Abnormal Expression of Some Adipokines in 3T3-L1 Adipocytes

Cho SO, Kim MH, Kim H

BACKGROUND: Oxidative stress occurs in white adipose tissue and dysregulates the expression of adipokines secreted from adipocytes. Since adipokines influence inflammation, supplementation with antioxidants might be beneficial for preventing oxidative...
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Innate Immune Response to Viral Infections in Primary Bronchial Epithelial Cells is Modified by the Atopic Status of Asthmatic Patients

Moskwa S, Piotrowski W, Marczak J, Pawełczyk M, Lewandowska-Polak A, Jarzębska M, Brauncajs , Głobińska A, Górski P, Papadopoulos NG, Edwards MR, Johnston S, Kowalski M

PURPOSE: In order to gain an insight into determinants of reported variability in immune responses to respiratory viruses in human bronchial epithelial cells (HBECs) from asthmatics, the responses of HBEC...
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Diagnostic Value of Combining Tumor and Inflammatory Markers in Lung Cancer

Yoon HI, Kwon OR, Kang KN, Shin YS, Shin HS, Yeon EH, Kwon KY, Hwang I, Jeon YK, Kim Y, Kim CW

BACKGROUND: Despite major advances in lung cancer treatment, early detection remains the most promising way of improving outcomes. To detect lung cancer in earlier stages, many serum biomarkers have been...
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The Changes of Pro-inflammatory Cytokines in Serum according to the Reperfusion Time after Ischemia of Left Common Iliac Artery in Mice

Park KS, Kim SJ, Seo Y

Ischemia-reperfusion injury arises from the restoration of blood supply after ischemia. Both reactive oxygen species and various cytokines produced by activated immune cells are the primary causal risk factors for...
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Cobalt Chloride Attenuates Oxidative Stress and Inflammation through NF-kappaB Inhibition in Human Renal Proximal Tubular Epithelial Cells

Oh SW, Lee YM, Kim S, Chin HJ, Chae DW, Na KY

We evaluated the effect of cobalt chloride (CoCl2) on TNF-alpha and IFN-gamma-induced-inflammation and reactive oxygen species (ROS) in renal tubular epithelial cells (HK-2 cells). We treated HK-2 cells with CoCl2...
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Development of intestinal ischemia/reperfusion-induced acute kidney injury in rats with or without chronic kidney disease: Cytokine/chemokine response and effect of alpha-melanocyte-stimulating hormone

Skottx M, Norregaard R, Birke-Sorensen H, Palmfeldt , Kwon TH, Jonassen T, Frokiaer J, Nielsen S

  • KMID: 2224271
  • Kidney Res Clin Pract.
  • 2014 Jun;33(2):79-88.
BACKGROUND: The primary aim of the study was to investigate the cytokine/chemokine response in the kidney, lung, and liver following acute kidney injury (AKI). The secondary aim was to test...
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The Changes of Pro- and Anti-inflammatory Cytokines in Both Serum and Gastrocnemius Muscle of Mice after 2-hour Postischemic Reperfusion Injury

Kim SY

This study aimed to investigate the inflammatory changes and their main indicators according to the time-period of postischemic reperfusion injury confirmed by analyzing changes of both pro-inflammatory and anti-inflammatory cytokines...
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Rhinovirus-Infected Epithelial Cells Produce More IL-8 and RANTES Compared With Other Respiratory Viruses

Chun YH, Park JY, Lee H, Kim HS, Won S, Joe HJ, Chung WJ, Yoon JS, Kim HH, Kim JT, Lee JS

PURPOSE: The environmental factors human rhinoviruses (HRVs) and house dust mites (HDMs) are the most common causes of acute exacerbations of asthma. The aim of this study was to compare...
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The Levels of Pro-Inflammatory Factors Are Significantly Decreased in Cerebral Palsy Patients Following an Allogeneic Umbilical Cord Blood Cell Transplant

Bae SH, Lee HS, Kang MS, Strupp BJ, Chopp M, Moon J

  • KMID: 1426155
  • Int J Stem Cells.
  • 2012 May;5(1):31-38.
BACKGROUND AND OBJECTIVES: The transplantation of human umbilical cord blood cells (hUCBCs) has been shown to attenuate the unregulated activation of microglia in a rat model of cerebral palsy (CP)....
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Decreased Expression of FOXP3 in Nasal Polyposis

Roongrotwattanasiri K, Pawankar R, Kimura S, Mori S, Nonaka M, Yagi T

PURPOSE: The pathogenesis of nasal polyposis (NP) is unclear. Eosinophils and mast cells are considered to play important roles in this process. In addition, the levels of Th2-type cells are...
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Effect of respiratory syncytial virus infection on regulated on activation, normal T-cells expressed and secreted production in a murine model of asthma

Ju Y, Choi SJ, Lee H, Kim HS, Won S, Chun YH, Yoon JS, Kim HH, Lee JS

PURPOSE: Synthesis of regulated on activation, normal T-cells expressed and secreted (RANTES) in the airway has previously been shown to be elevated after respiratory syncytial virus (RSV) infection. However, since...
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Role of Salvia miltiorrhiza for Modulation of Th2-derived Cytokines in the Resolution of Inflammation

Moon S, Shin S, Kim S, Oh HE, Han S, Lee S, Kim K

BACKGROUND: Salvia miltiorrhiza (SM) has been used to treat inflammatory diseases including edema and arthritis; however, the anti-inflammatory mechanism of SM action remains unresolved. METHODS: The effects of an ethanol extract of...
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Comparison of Serum Interleukin-8 and Regulated on Activation in Normal T-Cell Expressed and Secreted Levels in Atopic and Non-Atopic Children with Lower Respiratory Tract Infections

Kim SJ, Choi SJ, Lee JG, Kim HS, Lee HS, Oh EY, Jeon YH, Kim E, Yoon JS, Kim HH, Kim JT, Lee JS

  • KMID: 2315079
  • Pediatr Allergy Respir Dis.
  • 2011 Jun;21(2):78-85.
PURPOSE: Several studies have shown that viral respiratory infections induce more severe respiratory symptoms in atopic patients than in normal subjects. We attempted to investigate if there is any difference...
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Analysis of CCL5 Concentration in Tears of Dry Eye Patients

Choi W, Lee SH, Yoon KC

PURPOSE: To investigate the expression of CCL5/RANTES (regulated upon activation, normal T cell expressed and secreted) in the tears of dry eye patients. METHODS: Forty patients with dry eye (15 Sjogren's...
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Infliximab Therapy Impacts the Peripheral Immune System of Immunomodulator and Corticosteroid Naive Patients with Crohn's Disease

Kato K, Fukunaga K, Kamikozuru K, Kashiwamura S, Hida N, Ohda Y, Takeda N, Yoshida K, Iimuro M, Yokoyama Y, Kikuyama R, Miwa H, Matsumoto

  • KMID: 2167272
  • Gut Liver.
  • 2011 Mar;5(1):37-45.
BACKGROUND/AIMS: Infliximab (IFX), an antibody to tumor necrosis factor, (TNF)-alpha has efficacy in treating Crohn's disease (CD). However, knowledge of the potential effects of IFX on patients' immune profiles is...
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Association Study between CCL-2 and CCL-5 Polymorphisms and Clinicopathological Characteristics of Childhood IgA Nephropathy

Hahn WH, Suh JS, Cho BS

  • KMID: 2322021
  • J Korean Soc Pediatr Nephrol.
  • 2010 Apr;14(1):51-61.
PURPOSE: Previous studies have suggested that Chemokine (C-C motif) ligand-2 (CCL-2; also known as MCP-1) and CCL-5 (also known as RANTES) are possibly associated with the pathogenesis of various inflammatory...
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Downregulation of Angiotensin II-Induced 12-Lipoxygenase Expression and Cell Proliferation in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats by CCL5

Kim JH, Kim HS

Angiotensin II (Ang II) plays an important role in vascular hypertension. The role of the chemokine CCL5 on Ang II-induced activities in vascular smooth muscle cells (VSMCs) has not been...
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The Role of the Peripheral Chemokine, CCL3, in Hyperalgesia following Peripheral Nerve Injury in the Rat

Leem JW, Lee HJ, Nam TS, Yoon DM

BACKGROUND: Upregulation of one type of the pro-inflammatory chemokine (CCL2) and its receptor (CCR2) following peripheral nerve injury contributes to the induction of neuropathic pain. Here, we examined whether another...
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Analysis of Intraocular Chemokine and Chemokine Receptor in Patients with HLA-B27-associated Anterior Uveitis

Kim TW, Chung H, Yu HG

  • KMID: 2337665
  • J Korean Ophthalmol Soc.
  • 2008 Sep;49(9):1475-1482.
PURPOSE: To evaluate the expression of chemokine and chemokine receptors in the aqueous humor (AH) of patients with recurrent anterior uveitis (AU) in terms of HLA-B-27-association. METHODS: Patients with endogenous uveitis...
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IL-4-deficient Mice Aggravate Hypersensitivity Pneumonitis

Hwang SJ, Chung DH

BACKGROUND: Hypersensitivity pneumonitis (HP) comprises a group of lung diseases resulting from repeated inhalation of various antigens such as Saccharopolyspora rectivirgula (SR). HP is categorized as a Th1 disease. Therefore,...
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