J Korean Soc Pediatr Nephrol.  2010 Apr;14(1):51-61.

Association Study between CCL-2 and CCL-5 Polymorphisms and Clinicopathological Characteristics of Childhood IgA Nephropathy

• Hahn WH
• Suh JS
• Cho BS

Abstract

PURPOSE
Previous studies have suggested that Chemokine (C-C motif) ligand-2 (CCL-2; also known as MCP-1) and CCL-5 (also known as RANTES) are possibly associated with the pathogenesis of various inflammatory and non-inflammatory renal diseases. The present study was conducted to investigate association of polymorphisms of CCL-2 and CCL-5 genes with childhood IgA nephropathy (IgAN).
METHODS
The authors analyzed six single nucleotide polymorphisms (SNPs) of CCL-2 and CCL-5 in 196 pediatric IgAN patients and in 285 healthy controls. We compared variations in SNPs between two several sets of IgAN subgroups, allocated by presence of proteinuria (>4 mg/m2/hour), podocyte foot process effacement, and pathologically advanced disease markers, such as interstitial fibrosis, tubular atrophy, or global sclerosis.
RESULTS
Genotypic data of IgAN patients and controls showed no significant SNP frequency difference in both of of CCL-2 and CCL-5. Even though two linkage disequilibrium blocks were formed, there was no significance in the haplotype analysis. In the patient subgroup analysis, no SNP of CCL-2 and CCL-5 was found to be associated with the presence of proteinuria, podocyte foot process effacement, and pathologically advanced disease markers.
CONCLUSION
Our data indicate that no association exists between CCL-2 and CCL-5 SNPs and childhood IgAN susceptibility, and presence of proteinuria, podocyte foot process effacement, and pathologic progression of IgAN.

Keyword

CCL-2; MCP-1; CCL-5; RANTES; Chemokine; Polymorphism; IgA nephropathy; Childhood

MeSH Terms

Atrophy
Chemokine CCL5
Fibrosis
Foot
Glomerulonephritis, IGA
Haplotypes
Humans
Immunoglobulin A
Linkage Disequilibrium
Podocytes
Polymorphism, Single Nucleotide
Proteinuria
Chemokine CCL5
Immunoglobulin A