Yeungnam Univ J Med.  2007 Dec;24(2):129-136.

Chemokines Expression in Children with a Non-productive Cough

• Lee YH
• Kim HS

Abstract

PURPOSE: To evaluate the chemokine expression in children with a non-productive cough.
MATERIALS AND METHODS
Six children with a non-productive cough who visited Yeungnam University Hospital were evaluated for the mRNA expression of interferon-gamma-inducible protein 10(IP-10), macrophage cationic protein 1 and 3 (MCP-1, 3), interleukin (IL)-8, regulated upon activation in normal T cells expressed and secreted (RANTES), eotaxin and growth-related oncogene-alpha (Gro-alpha) using the reverse transcription polymerase chain reaction.
RESULTS
The chemokines IP-10 and MCP-3 were expressed in all samples. The chemokine RANTES was expressed in five cases, and IL-8 was expressed in three among them. However, eotaxin, Gro-alpha and MCP-1 were not expressed at all. The expression of chemokine MCP-3, RANTES and IL-8 were suppressed after the resolution of coughing in just one available case.
CONCLUSION
The chemokines MCP-3, RANTES and IL-8 may contribute to airway inflammation in children with a non-productive cough, whereas IP-10 is of secondary importance in this condition.

Keyword

Chemokine expression; Non-productive cough; Childhood

MeSH Terms

Chemokine CCL5
Chemokines*
Child*
Cough*
Humans
Inflammation
Interleukin-8
Interleukins
Macrophages
Polymerase Chain Reaction
Reverse Transcription
RNA, Messenger
T-Lymphocytes
Chemokine CCL5
Chemokines
Interleukin-8
Interleukins
RNA, Messenger