Pediatr Allergy Respir Dis.  2001 Mar;11(1):33-40.

The Effect of Respiratory Syncytial Virus Infection on the Production of Interleukin-5 and RANTES in Bronchiolitis

• Hyun JH
• Lee JS

Abstract

Purpose
Bronchiolitis, one of the most common lower respiratory tract diseases in infants, is similar clinical aspects to bronchial asthma. Respiratory syncytial virus (RSV) bronchiolitis than non-RSV bronchiolitis predisposes to later development of bronchial asthma. However, the role of RSV in these disease caused by airway inflammation has not been fully elucidated. This study was conducted to evaluate the effect of RSV infection on the production of IL-5 and RANTES in bronchiolitis.
METHODS
We measured ECP, RANTES, IL-5 levels in nasopharyngeal aspirated fluids from 20 infants with RSV bronchiolitis(RS group) and 20 infants with non-RSV bronchiolitis(non-RS group) and 15 infants without pulmonary or gastrointestinal viral diseases(control group).
RESULTS
ECP and RANTES in both RS and non-RS groups were significantly higher than in controls. ECP and RANTES in RS group were significantly higher than in non-RS group. IL-5 was only significantly higher in RS group than in controls. RANTES and ECP levels were significantly correlated in both RS and non-RS groups. IL-5 and ECP levels showed significant correlations only in RS group. IL-5 showed a higher correlation with ECP than RANTES.
CONCLUSION
RSV infection of the airway promotes the production of IL-5 and RANTES followed by activation of eosinophiles. And IL-5 might play more important roles than RANTES in RSV bronchiolitis.

Keyword

Respiratory syncytial virus; Interleukin-5; RANTES; Eosinophil cationic protein; Bronchiolitis

MeSH Terms

Asthma
Bronchiolitis*
Chemokine CCL5*
Eosinophil Cationic Protein
Eosinophils
Humans
Infant
Inflammation
Interleukin-5*
Respiratory Syncytial Viruses*
Respiratory Tract Diseases
Chemokine CCL5
Eosinophil Cationic Protein
Interleukin-5