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Relationships between lung function and clinical findings in school-age survivors of preterm birth

Kim YH, Jeong JE, Chung HL, Jang YY

Purpose: Survivors of preterm birth are at high risk of chronic pulmonary disease. We examined lung function in the school-age children born preterm and investigated the relationship between lung function...
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Real-world treatment pattern of mycoplasma pneumonia in hospitalized children: A multicenter retrospective study

Lee YJ, Ahn YM, Jang GC, Chung HL, Chung EH, Hwang YH, Shim JY

Purpose: Macrolide-refractory Mycoplasma pneumoniae pneumonia (MP) has markedly increased since 2003 and corticosteroids or second-line antibiotics, such as fluoroquinolones or tetracyclines, was considered an alternative treatment modality in macrolide-refractory MP....
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Risk Factors and Comorbidities Associated With the Allergic Rhinitis Phenotype in Children According to the ARIA Classification

Jung S, Lee SY, Yoon J, Cho HJ, Kim YH, Suh DI, Yang SI, Kwon JW, Jang GC, Sun YH, Woo SI, Youn YS, Park KS, Lee E, Cho HJ, Kook MH, Yi HR, Chung HL, Kim JH, Kim HY, Jung JA, Woo HO, Lee JK, Chang WS, Do NH, Cho H, Hong SJ

PURPOSE: Data are lacking on the association between the allergic rhinitis (AR) phenotype and sensitization to specific allergens or bronchial hyperresponsiveness (BHR) in children. We here investigated risk factors and...
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SYM 2081 Exerts Neuroprotective Effect Modulating Anti-Apoptosis in the Hypoxic-Ischemic Brain Injury of Neonatal Rats

Park JK, Jang YY, Jeong JE, Lee EJ, Choi EJ, Chung HL, Kim WT

OBJECTIVE: SYM 2081 ((2S,4R)-4-methylglutamic acid), an agonist and functional antagonist of the kainite receptor, has shown a neuroprotective effect in neurodegenerative diseases in adults but little is known concerning perinatal...
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A novel compound heterozygous mutation in DNAH5 in a Korean neonate with primary ciliary dyskinesia

Lee NW, Jeong JE, Jang YY, Chung HL

Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disease affecting motile cilia. A female neonate was hospitalized with respiratory distress 72 hours after birth and showed concurrent situs inversus. She...
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Indoor pet ownership in infancy is a risk factor for the development of sensitization to pets and asthma in childhood

Jung S, Noh SR, Lee SY, Yoon J, Cho HJ, Kim YH, Suh DI, Yang SI, Kwon JW, Jang GC, Sun YH, Woo SI, Youn YS, Park KS, Lee E, Cho HJ, Kook MH, Yi HR, Chung HL, Kim JH, Kim HY, Jung JA, Woo HO, Hong SJ

PURPOSE: It is controversial whether indoor pet exposure is either a risk or protective factor developing sensitization to pet allergens or asthma. Therefore, we investigated whether indoor pet ownership entails...
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Seasonal patterns and etiologies of croup in children during the period 2010–2015: A multicenter retrospective study

Lee YJ, Kim HB, Kim BS, Kim CK, Kim CH, Kim HY, Kim S, Kim Y, Park C, Seo JH, Sol IS, Sung M, Song MS, Song DJ, Ahn YM, Oh HL, Yu J, Lee KS, Lee E, Lee JS, Jang GC, Jang YY, Chung EH, Chung HL, Choi SM, Choi YJ, Han MY, Yang HJ, Shim JY, Kim JT, The Pneumonia & Respiratory Disease Study Group of Korean Academy of Pediatric Allergy and Respiratory Disease

PURPOSE: Croup is known to have epidemics in seasonal and biennial trends, and to be strongly associated with epidemics of parainfluenza virus. However, seasonal and annual epidemics of croup have...
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Multicenter Adherence Study of Asthma Medication for Children in Korea

Kim CK, Callaway Z, Choi J, Kim HB, Kwon EM, Chang YS, Rha YH, Hong SJ, Oh JW, Kim HH, Lim DH, Kim SW, Park KS, Cho YH, Chung HL, Park HJ, Jung SG, Kang IJ, Hyun MC, Oh MY, Jung JA, Kim MS, Shim JY, Kim JT, Koh YY, KAPARD Work Group on Asthma Medication Compliance

PURPOSE: Adherence is a major component of successful medical treatment. However, non-adherence remains a barrier to effective delivery of healthcare worldwide. METHODS: Twenty healthcare facilities (secondary or tertiary hospitals) belonging to...
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Literature review and future strategies of childhood respiratory diseases in Korea

Han MY, Chung HL, Ahn YM, Shim JY

Thirty years have passed since the Korean Association of Pediatric Allergy and Respiratory Disease was founded. There have been great changes in the pattern of respiratory diseases in Korean children...
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Prevalence, Risk Factors and Cutoff Values for Bronchial Hyperresponsiveness to Provocholine in 7-Year-Old Children

Jung S, Suh DI, Lee SY, Yoon J, Cho HJ, Kim YH, Yang SI, Kwon JW, Jang GC, Sun YH, Woo SI, Youn YS, Park KS, Cho HJ, Kook MH, Yi HR, Chung HL, Kim JH, Kim HY, Jung JA, Woo HO, Hong SJ

BACKGROUND: A US Food and Drug Administration (FDA)-approved drug methacholine chloride (Provocholine®) was recently introduced to Korea where it is now widely used in clinical practice. We aimed to evaluate...
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Neuroprotective effects of erythropoietin against hypoxic injury via modulation of the mitogen-activated protein kinase pathway and apoptosis

Jeong JE, Park JH, Kim CS, Lee SL, Chung HL, Kim WT, Lee EJ

PURPOSE: Hypoxic-ischemic encephalopathy is a significant cause of neonatal morbidity and mortality. Erythropoietin (EPO) is emerging as a therapeutic candidate for neuroprotection. Therefore, this study was designed to determine the...
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Neuroprotective Effects of SYM 2081, Targeting Kainate Receptors in the Neonatal Hypoxic-Ischemic Brain Injury

Lee JH, Lee EJ, Jang YY, Jeong JE, Chung HL, Kim WT

PURPOSE: Glutamate induced excitotoxicity has been implicated as a major factor of central neuronal death in neonatal hypoxic-ischemic (HI) injury. Kainate receptors (KARs) are one of glutamatergic receptors involving glutamate...
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Significance of total serum IgE in children with lower respiratory infections due to respiratory syncytial virus

Jang YY, Lee HS, Jeong JE, Hong SJ, Park HJ, Lee KH, Kim W, Chung HL

PURPOSE: Respiratory syncytial virus (RSV) is known to induce Th2 immune response with increased IgE production. We investigated serum IgE levels in RSV bronchiolitis/pneumonia (RSV-LRI) in relation to disease severity. METHODS:...
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Bee Venom Exerts Neuroprotective Effects on Neuronal Cells and Astrocytes under Hypoxic Conditions Through MAPK Signaling Pathways

Lee EJ, Kim BJ, Jeong JE, Chung HL, Yang EK, Kim WT

PURPOSE: Hypoxic-ischemic brain injuries influence the mechanisms of signal transduction, including mitogen-activated protein kinase (MAPK) that regulates gene expression through transcription factor activity. Several attempts have been made to use...
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Clinical characteristics related to onset age of wheeze in school-age children and adolescents with asthma

Jang GC, Shim JY, Ahn YM, Jung JA, Kim SW, Chung HL, The Group for the Study of Asthma in Adolescent Children

PURPOSE: We aimed to investigate the clinical characteristics and their relationship with the onset age of wheeze in school-age children and adolescents with asthma. METHODS: Three hundred twenty-six patients, aged 6...
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ERRATUM: Affiliation Correction. Evaluation of the association of vegetation of allergenic plants and pollinosis with meteorological changes

Kim JH, Oh JW, Lee HB, Kim SW, Chung HL, Kook MH, Park KS, Kim BS, Kim JK, Lee DJ, Paik WK, Kim KR, Lee HL, Choi YJ, Yu SD, Kim JH, Cho YS

According to the author's request, in this paper, the eighth author's (Bong-Seong Kim) affiliation should be corrected.
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Clinical significance of increased vascular endothelial growth factor, transforming growth factor-beta1, and YKL-40 in the serum of children with asthma

Jang YY, Lee HS, Jeong JE, Lee EJ, Hong SJ, Park HJ, Lee KH, Kim W, Chung HL

PURPOSE: Vascular endothelial growth factor (VEGF), transforming growth factor beta1 (TGF-beta1), and platelet derived growth factor (PDGF) are known to be involved in the pathogenesis of inflammation and remodeling in...
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Effects of Dizocilpine (MK-801) via Up-modulation of N-methyl-D-aspartate (NMDA) Receptors on Hypoxic-Ischemic Brain Injury in Neonatal Rats

Kim JH, Lee HJ, Lee EJ, Choi EJ, Kim JK, Chung HL, Kim WT

OBJECTIVE: Several studies have demonstrated the neuroprotective effects of (+)-MK-801 hydrogen maleate (dizocilpine), in various animal models of hypoxic-ischemic (HI) brain injury. However limited data are available on the neonatal...
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Evaluation of the association of vegetation of allergenic plants and pollinosis with meteorological changes

Kim JH, Oh JW, Lee HB, Kim SW, Chung HL, Kook MH, Park KS, Kim BS, Kim JK, Lee DJ, Paik WK, Kim KR, Lee HL, Choi YJ, Yu SD, Kim JH, Cho YS

PURPOSE: There are a number of reports suggesting that widespread propagation of weeds and high concentration of weed pollen have been contributed to climate change. We investigated the interrelationship between...
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Increased serum surfactant protein-D in the infants with acute respiratory syncytial virus bronchiolitis

Chu MA, Lee EJ, Park HJ, Lee KH, Kim WT, Chung HL

PURPOSE: Collectin family is an important component of innate immunity, of which surfactant protein (SP)-D and mannose-binding lectin (MBL) are the most characterized. We examined SP-D and MBL in young...
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