Korean J Cerebrovasc Surg.
2004 Sep;6(2):155-159.
Effect of Hyperglycemia in Cerebrovascular Disease
- Affiliations
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- 1Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. schong@smc.samsung.co.kr
Abstract
- Ischemic brain injury is associated with a stress response that includes hyperglycemia. Hyperglycemia is believed to aggravate cerebral ischemia. To review animal and human studies on the relationship between transient hyperglycemia and brain ischemia that elucidate some of the mechanisms for the deleterious effect of hyperglycemia, we searched computerized data sources and articles for human studies and experimental models that evaluated the association between hyperglycemia and cerebrovascular disorders containing ischemic brain injury. Most studies have shown that hyperglycemia in patients with ischemic brain injury is associated with a worse clinical outcome. The mechanisms of damaging process of hyperglycemia include tissue lactic acidosis, accumulation of extracelluar glutamate, blood-brain barrier disruption and brain edema formation.
