Korean J Dermatol.  2002 Mar;40(3):295-299.

A Case of Adult T-cell leukemia / lymphoma

• Ryu JH
• Park JS
• Hong SJ
• Hong SI
• Son SJ
• Suh CI

Abstract

Adult T-cell leukemia/lymphoma (ATLL) is an often aggressive and fatal malignancy of mature CD4+ T lymphocytes, characterized by leukemia, lymphadenopathy, hypercalcemia and lytic bone lesions. Diagnosis of ATLL is based cm abnormal T lymphocytes in the peripheral blood and histologically and cytologically proven lymphoid malignancy with T cell surface antigens. Anti-HTLV-I serum antibodies and demonstration of clonality to HTLV-I proviral DNA are included. We report a case of ATLL in a 64-year-old man who had a painful nodule on the right cheek and multiple scattered papules and nodules on the trunk for 2 months. He had multiple cervical and axillary lymph node enlargements and hepatosplenomegaly. On laboratory finding peripheral leukocytes count was 33,400/mm3 with 63% atypical lymphocytes. Clover-shaped lyrnphocytes with multilobulated nuclei were found in peripheral blood and bone marrow. Histologic findings showed dense bandlike infiltrations of atypical lymphocytes in the dermis with angiocentricity. The surface phenotype of these abnormal cells were CD2+, CD3+, CD4+, CD30+ and HLA-DR+ and HTLV-I specific antibodies were found.

Keyword

Adult T-cell leukemia/lymphoma; HTLV-1

MeSH Terms

Adult*
Antibodies
Antigens, Surface
Bone Marrow
Cheek
Dermis
Diagnosis
DNA
Human T-lymphotropic virus 1
Humans
Hypercalcemia
Leukemia
Leukemia-Lymphoma, Adult T-Cell*
Leukocytes
Lymph Nodes
Lymphatic Diseases
Lymphocytes
Lymphoma*
Middle Aged
Phenotype
T-Lymphocytes
Antibodies
Antigens, Surface
DNA