Ann Dermatol.  2008 Jun;20(2):77-81. 10.5021/ad.2008.20.2.77.

A Case of Aggressive NK/T-cell Lymphoma/Leukemia with Cutaneous Involvement in Adolescence

• Kim SH
• Ko WT
• Suh MK
• Ha GY
• Kim JR

• KMID: 2172089
• DOI: http://doi.org/10.5021/ad.2008.20.2.77

Abstract

NK/T-cell lymphoma (NKTCL) is characterized by the expression of the NK-cell antigen CD56. Non-nasal NK/T-cell lymphomas are subdivided into primary cutaneous and 4 subtypes of secondary cutaneous lymphomas; nasal type, aggressive, blastic (blastoid), and other specific NK-like cell lymphoma. Aggressive NK/T-cell lymphoma/leukemia is a rare leukemic variant of nasal type NKTCL. We herein report a rare case of aggressive NK/T-cell lymphoma/leukemia with cutaneous involvement in adolescence.

Keyword

Adolescence; Aggressive NK/T-cell lymphoma/leukemia

MeSH Terms

Adolescent
Humans
Lymphoma

Figure

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  Fig. 1 Multiple, asymptomatic, deep-seated, erythematous nodules with central necrotic crusts on the left upper eyelid (A), neck (B) and left thigh (C).

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  Fig. 2 (A) Peripheral blood smear shows atypical immature cell (Wright, ×1,000). (B) Bone marrow biopsy shows infiltrations of hemophagocytic cells and atypical immature cell (Wright, ×1,000).

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  Fig. 3 (A) Dense polymorphous infiltrate with extensive necrosis throughout the dermis (H&E, ×40). (B) Perivascularly infiltrative atypical polymorphic lymphoid cells (H&E, ×400).

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  Fig. 4 (A) Immunohistopathologic findings shows positive reactions against CD56 (×200). (B) EBV genomes in infiltrative tumor cells (In situ hybridization, ×200).

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