Korean J Biol Psychiatry.
2013 Sep;20(3):91-96.
Association Study between Treatment Response of Amisulpride and Dopamine D3 Receptor Gene Polymorphisms
- Affiliations
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- 1Department of Psychiatry, Gil Medical Center, Gachon University School of Medicine, Incheon, Korea.
- 2Department of Psychiatry, Korea University College of Medicine, Seoul, Korea.
- 3Department of Psychiatry, Kyungpook National University School of Medicine, Daegu, Korea.
- 4Department of Psychiatry, Catholic University of Daegu School of Medicine, Daegu, Korea. rheejh@cu.ac.kr
- 5Department of Psychiatry, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.
- 6Department of Psychiatry, College of Medicine, Yeungnam University, Daegu, Korea.
- 7Department of Psychiatry, Dongguk University College of Medicine, Gyeongju Hospital, Gyeongju, Korea.
- 8Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, Korea.
- 9Institute of Brain Research, Chungnam National University, Daejeon, Korea.
Abstract
OBJECTIVES
The aim of this study is to evaluate the association between rs6280 and rs905568 genetic polymorphism of DRD3 gene and the treatment response of amisulpride.
METHODS
After six weeks treatment of amisulpride, 125 schizophrenia patients were interviewed based on the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression-Severity (CGI-S). The genotyping for rs6280 and rs905568 was performed using TaqMan single nucleotide polymorphism (SNP) genotyping assay.
RESULTS
There was no significant difference in the frequency of genotype and allele of rs6280 between the responders and non-responders based on the total, positive, and general score of PANSS and CGI-S score. However, there was a significant association between this SNP and treatment response in the negative score of PANSS (chi2 = 5.23, p = 0.022). There was no significant association between rs905568 and the response in positive, negative, general, and total PANSS score and CGI-S score.
CONCLUSIONS
This is the first positive association study between DRD3 gene and the treatment response of negative symptoms to amisulpride in Korean schizophrenia patients. A larger scale research on more SNP of the DRD3 gene will make a progress in the study of pharmacogenetics on the treatment response of the amisulpride.
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