Korean J Infect Dis.  1998 Oct;30(5):450-459.

In Vitro Activities of Cefminox against Enterobacteriaceae Species, Haemophilus influenzae, and Methicillin-Susceptible Staphylococcus aureus

• Chong Y
• Lee K
• Shin HB
• Chung JL

Abstract

BACKGROUND
Recent clinical isolates of bacteria often produce various beta-lactamases, for example, extended spectrum beta-lactamase (ESBL) by some species of Enterobacteriaceae, TEM beta-lactamase by Haemophilus influenzae, and penicillinase by methicillin-susceptible Staphylococcus aureus (MSSA). Cefminox, a commonly used cephamycin, is stable to various beta-lactamases, but its activity against recent clinical isolates has not been evaluated. The aim of this study was to determine the activities of cefminox against recent clinical isolates of Enterobacteriaceae, H. influenzae, and MSSA.
METHODS
The organisms, isolated from Severance Hospital patients during 1997 to 1998, were kept frozen until the test. Antimicrobial susceptibility was determined by the NCCLS agar dilution method.
RESULTS
All 30 isolates of Escherichia coli and 90% of 30 Klebsiella pneumoniae isolates were susceptible to cefminox, cefotetan and amikacin. All of the Enterobacter cloacae and Serratia marcescens, and 86% of Citrobacter freundii isolates were susceptible to amikacin. All of the 15 isolates each of Proteus mirabilis, P. vulgaris and Morganella morganii were susceptible to cefminox, cefotetan, cefotaxime, ceftazidime, and aztreonam, while all of the Providencia spp. were susceptible to ceftazidime and aztreonam. All of the 29 H. influenzae isolates were susceptible to cefminox, cefotaxime, and levofloxacin, while all MSSA isolates were susceptible to cefoxitin and cotrimoxazole.
CONCLUSION
Cefminox is more active than the other beta-lactams against Enterobacteriaceae including, ESBL- producing E. coli, and K. pneumoniae.

Keyword

Enterobacteriaceae; Haemophilus influenzae; Staphylococcus aureus; Cefminox; Antimicrobial susceptibility

MeSH Terms

Agar
Amikacin
Aztreonam
Bacteria
beta-Lactamases
beta-Lactams
Cefotaxime
Cefotetan
Cefoxitin
Ceftazidime
Citrobacter freundii
Enterobacter cloacae
Enterobacteriaceae*
Escherichia coli
Haemophilus influenzae*
Haemophilus*
Humans
Influenza, Human
Klebsiella pneumoniae
Levofloxacin
Morganella morganii
Penicillinase
Pneumonia
Proteus mirabilis
Providencia
Serratia marcescens
Staphylococcus aureus*
Staphylococcus*
Trimethoprim, Sulfamethoxazole Drug Combination
Agar
Amikacin
Aztreonam
Cefotaxime
Cefotetan
Cefoxitin
Ceftazidime
Penicillinase
beta-Lactamases
beta-Lactams