Korean J Crit Care Med.  2002 Nov;17(2):95-99.

The Effects of Propofol on Blood-Brain Barrier Disruption with Mannitol Infusion in Cervical Sympathetic Nerve Blocked Rats

• Lee JY
• Yoon SH
• Kim JH
• Chae YJ
• Lee YJ
• Kim JS
• Moon BK

Abstract

BACKGROUND: Blood brain barrier disruption (BBBD)increases therapeutic agents delivery to brain diseases.Increasing the delivery of therapeutic drugs to the brainimproves out come f or patients with brain tumors.Cervical sympathetic chain block can increase the degree of mannitol induced blood brain barrier disruption in rats.Anesthetic agents may modify hyperosmolar blood brain barrier disruption.Therefore we evaluated the effecfs of pentobarbital and propofol on mannitol induced blood brain barrier disruption(BBBD)in cervical sympathetic nerve blocked rats.
METHODS
14 male Sprague-Dawley rats were divided into 2 groups.Intravenous pentobarbital (group 1,n=7)and propofol (group 2,n=7)were administrated.Rats was blocked with 0.5% bupivacaine on right cervical sympathetic chain.All rats received 37degrees C,25%mannitol (1.75 g/kg) via right carotid artery.BBBD was estimated by Evans blue staining in cerebral hemisphere.
RESULTS
Both groups showed BBBD in right side hemisphere and there was no significant difference between group 1 and group 2 in right side hemisphere.
CONCLUSIONS
The results suggest that propofol could be used to be anesthetics for BBBD in cervical sympathetic blocked rats.

Keyword

Blood brain barrier disruption; Cervical sympathetic chain block; Pentobarbital; Propofol

MeSH Terms

Anesthetics
Animals
Autonomic Nerve Block*
Blood-Brain Barrier*
Brain
Bupivacaine
Cerebrum
Evans Blue
Humans
Male
Mannitol*
Pentobarbital
Propofol*
Rats*
Rats, Sprague-Dawley
Anesthetics
Bupivacaine
Evans Blue
Mannitol
Pentobarbital
Propofol