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Ethanol Extract of Perillae Herba Enhances Pentobarbital-Induced Sleep and Non-Rapid Eye Movement (NREM) Sleep through GABA(A)-ergic Systems

Kwon YO, Ha TW, Oh KW

Perillae Herba has been traditionally used for the sedation in the oriental countries. Therefore, this study was conducted to determine whether Perillae Herba ethanol extract (PHEE) enhances pentobarbital-induced sleeping behaviors...
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Rosmarinic Acid Potentiates Pentobarbital-Induced Sleep Behaviors and Non-Rapid Eye Movement (NREM) Sleep through the Activation of GABA(A)-ergic Systems

Kwon YO, Hong JT, Oh KW

It has been known that RA, one of major constituents of Perilla frutescens which has been used as a traditional folk remedy for sedation in oriental countries, shows the anxiolytic-like...
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Sinomenine, an Alkaloid Derived from Sinomenium acutum Potentiates Pentobarbital-Induced Sleep Behaviors and Non-Rapid Eye Movement (NREM) Sleep in Rodents

Yoo JH, Ha TW, Hong JT, Oh KW

Sinomenium acutum has been long used in the preparations of traditional medicine in Japan, China and Korea for the treatment of various disorders including rheumatism, fever, pulmonary diseases and mood...
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Potentiation of decursinol angelate on pentobarbital-induced sleeping behaviors via the activation of GABA(A)-ergic systems in rodents

Woo JH, Ha TW, Kang JS, Hong JT, Oh KW

Angelicae Gigantis Radix (AGR, Angelica gigas) has been used for a long time as a traditional folk medicine in Korea and oriental countries. Decursinol angelate (DCA) is structurally isomeric decursin,...
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Quinpirole Increases Melatonin-Augmented Pentobarbital Sleep via Cortical ERK, p38 MAPK, and PKC in Mice

Hong SI, Kwon SH, Hwang JY, Ma SX, Seo JY, Ko YH, Kim HC, Lee SY, Jang CG

Sleep, which is an essential part of human life, is modulated by neurotransmitter systems, including gamma-aminobutyric acid (GABA) and dopamine signaling. However, the mechanisms that initiate and maintain sleep remain...
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Rhynchophylline, One of Major Constituents of Uncariae Ramulus et Uncus Enhances Pentobarbital-induced Sleep Behaviors and Rapid Eye Movement Sleep in Rodents

Yoo JH, Ha TW, Hong JT, Oh KW

Rhynchophylline (RP) is a major tetracyclic oxindole alkaloid of Uncariae Ramulus et Uncus which has been used to treat hypertension, seizures, pain and anxiety in the oriental countries. A recent...
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4-Hydroxybenzaldehyde, One of Constituents from Gastrodiae Rhizoma Augments Pentobarbital-induced Sleeping Behaviors and Non-rapid Eye Movement (NREM) Sleep in Rodents

Choi JJ, Kim YS, Kwon YO, Yoo JH, Chong MS, Lee MK, Hong JT, Oh KW

In the previous experiments, we reported that ethanol extract of Gastrodiae Rhizoma, the dried tuber of Gastrodia ElataBlume (Orchidaceae) increased pentobarbital-induced sleeping behaviors. These experiments were undertaken to know whether...
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Pachymic Acid Enhances Pentobarbital-Induced Sleeping Behaviors via GABA(A)-ergic Systems in Mice

Shah VK, Choi JJ, Han JY, Lee MK, Hong JT, Oh KW

  • KMID: 2170625
  • Biomol Ther.
  • 2014 Jul;22(4):314-320.
This study was investigated to know whether pachymic acid (PA), one of the predominant triterpenoids in Poria cocos (Hoelen) has the sedative-hypnotic effects, and underlying mechanisms are mediated via gamma-aminobutyric...
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G protein-coupled receptor, family C, group 5 (GPRC5B) downregulation in spinal cord neurons is involved in neuropathic pain

Chung HJ, Kim JD, Kim KH, Jeong NY

BACKGROUND: G protein-coupled receptor, family C, group 5 (GPRC5B), a retinoic acid-inducible orphan G-protein-coupled receptor (GPCR), is a member of the group C metabotropic glutamate receptor family proteins presumably related...
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Emergency euthanasia of cattle challenged with Escherichia coli O157:H7 - A case study for evaluating the response to an infectious disease outbreak

Gilroyed B, Reuter T, Kastelic J, McAllister TA

In the event of an infectious disease outbreak in cattle, carcasses must be disposed of in a rapid and contained manner. This brief communication details injection of a barbiturate to...
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Use of Continuous Venovenous Hemodiafiltration to Enhance the Elimination of Serum Pentobarbital before Diagnosis of Brain Death

Lee JM, Lee YJ, Bang ES, Chu IS, Kim SH

  • KMID: 2324218
  • J Korean Soc Transplant.
  • 2012 Jun;26(2):120-124.
Continuous venovenous hemodiafiltration (CVVHDF) was used to eliminate pentobarbital from the blood of a 30-year-old potentially brain dead male patient with traumatic intracranial hemorrhage after a motorcycle accident. The Acute...
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Comparison of the effects of propofol and pentobarbital on hydrogen peroxide-stimulated hepatic SNU761 cells

Lee JY, Shin JW, Lee EH, Baek SH, Ku SW, Kim JU

BACKGROUND: Propofol and barbiturates are both known to protect cells of several organs against ischemia/reperfusion injury, but there are few reports on any possible protective effects on human hepatocytes. We...
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Significance of Brain CT Angiography in Determination of Brain Death in a Patient with Barbiturate Coma Therapy after Subarachnoid Hemorrhage

Kim D, Kim SK, Jung KY, Kim ST, Chung CS, Seo DW

  • KMID: 2343257
  • J Korean Neurol Assoc.
  • 2007 Aug;25(3):372-376.
In determination of brain death, brain CT angiography (CTA) can be used as a new ancillary test to assist EEG which is the current gold standard. We report a patient...
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A Case of The Successful Treatment of Pentobarbital for Posthypoxic Action Myoclonus(Lance-Adams Syndrome) with Refractory Status Epilepticus

Kim DH, Kim SJ, Oh KI, Kwon YS, Son BK

  • KMID: 2329590
  • J Korean Child Neurol Soc.
  • 2006 Nov;14(2):342-347.
Lance-Adams syndrome is a rare complications of cardiorespiratory arrest. We report a 15-month-old child with Lance-Adams syndrome who fell into a refractory status epilepticus after a successful resuscitation after the...
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Alteration of Ionic Zinc Distribution in Rat Spinal Ganglion by Inflammatory Pain Stimulus: Autometallography

Lee B, Jun G, Kim YS, Lee B, Lee YI, Kim DJ, Jo SM

  • KMID: 2224492
  • Korean J Anat.
  • 2005 Dec;38(6):561-566.
This study was designed to investigate any correlation between the mechanism of pain development and changes of histochemically reactive zinc contents in the rat spinal ganglion following complete Freund's Adjuvant...
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A Comparative Study of Behavioral and immunohistological Changes after Spinal Cord Injury between Young and Adult Rats

Yang JY, Lee JK, Rhee KJ, Kim KC, Hong UP, Lee JB

  • KMID: 2399118
  • J Korean Orthop Assoc.
  • 2004 Sep;39(5):522-530.
PURPOSE: The aim of this study was to compare the behavioral and immunohistochemical changes in a spinal cord injury (SCI) between young and adult rats and to clarify the differences...
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Decrease in Zinc Concentration in the Rat Spinal Gray Matter Induced by Peripheral Nerve Ligation, and its Relations with Increased Pain Threshold

Kim SJ, Choi YH, Yu YC, Lee B, Jo SM

  • KMID: 2224499
  • Korean J Anat.
  • 2004 Aug;37(4):369-375.
This study was designed to investigate any correlation between the mechanism of pain development and changes of histochemically-reactive zinc contents in the rat spinal cords following peripheal nerve ligation. Male...
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Effects of IGF (Insulin-like growth factor) on sub-populated articular chondrocytes by Percoll density gradient

Lee HJ, Kim HJ, Cho HS, Park SR, Min BH

  • KMID: 2042111
  • J Korean Orthop Res Soc.
  • 2004 Apr;7(1):49-59.
PURPOSE: Articular chondrocytes have been known to have heterogeneity in articular cartilage. The different responses of chondrocytes to various cytokines and growth factors have been reported. These variations are likely...
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A Pediatric Case of Topiramate Treatment for Refractory Status Epilepticus

Kim SY, Kim JK, Lee JH

  • KMID: 1640576
  • J Korean Epilepsy Soc.
  • 2004 Dec;8(2):171-174.
The definition of refractory status epilepticus (RSE) is the state of epilepticus that persists for longer than 60 minutes despite an adequate dose of benzodiazepine and an antiepileptic drug. Topiramate...
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Ultrastructure of Fronto-Accumbens Synapses after Prefrontal Decortication of the Rat

Song HG, Ahn ET, Ko JS, Park KH

  • KMID: 2092810
  • Korean J Anat.
  • 2003 Oct;36(5):405-416.
Prefrontal cortex is called psycological cortex, since it deals with making up of individual personality, regulation of personal depth of feeling, working memory, planning, maintaining attention, etc. Whereas, nucleus accumbens...
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