Korean J Anesthesiol.  1988 Dec;21(6):882-888. 10.4097/kjae.1988.21.6.882.

The Effects of Vecuronium on Hemodynamics and Intracranial Pressure in Cats

Affiliations
  • 1Department of Anesthesiology, College of Medicine, Korea University, Seoul, Korea.

Abstract

We studied the cardiovascular and intracranial pressure(ICP) effects of Vecuronium in cats with normal and artificially increased ICP. Under pentobarbital and nitrous oxide anesthesia, monitors for ICP, Mean Arterial Pressure(MAP), Heart Rate(HR), and Central Venous Pressure(CVP) were placed in the cats. The cats were then divided into two groups: one with normal ICP( N-ICP) (n=8) and the other with artificially increased ICP (AI-ICP) (n=8). In the AI-ICP group, a size 8F Foley catheter was placed in the epidural space through a 5 mm trephined hole on the right parietal area. In each group, ICP, MAP, HR, CVP, and Cerebral Perfusion Pressure(CPP) were measured after Vecuronium injection(80ug/kg)(CPP=MAP-ICP). Results showed no statistically significant changes in cats with N-ICP and AI-ICP.

Keyword

Vecuronium; Intracranial pressure(ICP)
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