Korean J Anesthesiol.  1990 Apr;23(2):187-199. 10.4097/kjae.1990.23.2.187.

The Effect of Succinylcholine on the Intracranial Pressure in Cats

• Choi SJ
• Lee WH

• KMID: 2090527
• DOI: http://doi.org/10.4097/kjae.1990.23.2.187

Abstract

Succinylcholine (1.5mg/kg) without pretreatment, or succinylcholine (1.5mg/kg) with pretreatment by vecuronium (0.015 mg/kg, 0.045 mg/kg, 0.15 mg/kg) or d-tubocurarine (0.1 mg/kg, 0. 3 mg/ kg, 1mg/kg) was given to cats of the same genus (body weight 2.5-3.5kg) under subcutaneous urethane anesthesia to determine the effect of the intracrainal pressure increase in each method. The results are summarized as follows: 1) The intracranial pressure was significantly increased (0.005< p< 0.01)with the administration of succinylcholine(1.5mg/kg). 2)The intracranial pressure was not increased with the administration of vecuronium. 3)As the dosage of d-tubocuraine administration increased, the intracranial pressure was increased. 4)The increase of the intracranial pressure by succinylcholine was depressed dose-dependently by vecuronium pretreament. 5)The increase of the intracranial pressure by succinylcholine was depressed by d-tubocurarine(0.3mg/kg)pretreatment.

Keyword

Intracranial pressure; Succinylcholine; Vecuronium; d-tubocurarine

MeSH Terms

Anesthesia
Animals
Cats*
Intracranial Pressure*
Succinylcholine*
Tubocurarine
Urethane
Vecuronium Bromide
Succinylcholine
Tubocurarine
Urethane
Vecuronium Bromide