Korean J Anesthesiol.  1992 Apr;25(2):260-265. 10.4097/kjae.1992.25.2.260.

Modification of Atracurium or Vecuronium Blockade and Their Reversal by Succinylcholine in the Cat

• Shin YS
• Yoo ES
• Min SK
• Kim JR
• Park KW

• KMID: 2240576
• DOI: http://doi.org/10.4097/kjae.1992.25.2.260

Abstract

The interaction between succinylcholine(SCC) and non-depolarizer; atracurium or vecuronium, was investigated in 36 cats of either sex using the sciatic nerve-anterior tibialis muscle preparation. And also, its relation to the pseudocholinesterase activity was examined. The duration of action of vecuronium(6.5+/-1.3 to 7.3+/-2.2 minutes) in cats pretreated with SCC was greater than those(2.0+/-0.6 minutes) in non-pretreated cats. However, SCC had no influence on the duration of atracurium. The serum pseudocholinesterase activity was decreased after the injection of atracurium or neostigmine in contrast to vecuronium. The authors conclude that the prior administration of SCC prolongs the duration of vecuronium but not that of atracurium, and pseudocholinesterase activity is not related to the prolonging effect of SCC.

Keyword

Neuromuscular relaxants; succinylcholine; atracurium; vecuronium; Pharmacodynamics; interaction

MeSH Terms

Animals
Atracurium*
Cats*
Neostigmine
Pseudocholinesterase
Succinylcholine*
Vecuronium Bromide*
Atracurium
Neostigmine
Pseudocholinesterase
Succinylcholine
Vecuronium Bromide