Korean J Anesthesiol.  1989 Jun;22(3):409-412. 10.4097/kjae.1989.22.3.409.

Clinical Evaluation of Atracurium for Endotracheal Intubation

• Woo NS
• Lee YC

• KMID: 1751756
• DOI: http://doi.org/10.4097/kjae.1989.22.3.409

Abstract

The usefulness of nondepolarizing muscle relaxants for intubation is limited by a relatively slow onset of neuromuscular block compared to that achived with succinylcholine. But, authors have reported that larger doses of nondepolarizing muscle relaxants produce a more rapid onset of maximal neuromuscular block and conditions conductive to endotracheal intubation and recent reports support the use of the "priming principle in the clinical practice of anesthesiology. This phenomenon may apply to all nondepolarizing relaxants: it is reported to facilitated neuromuscular blockade and tracheal intubation when used with atracurium, vecurouium, alcuronium or pancuronium. In this study, administering a small subclinical dose of atracurium (75ug/kg) Smin. prior to the remainder of an intubating doae of atracurium (250ug/kg) had no different on grade of block for intubation compared to single IV bolus of atracurium (500ug/kg).

Keyword

Neuromuscular Relaxants-atracurium; Endotracheal Intubation-priming principle

MeSH Terms

Alcuronium
Anesthesiology
Atracurium*
Intubation
Intubation, Intratracheal*
Neuromuscular Blockade
Pancuronium
Succinylcholine
Alcuronium
Atracurium
Pancuronium
Succinylcholine