Korean J Anesthesiol.  1986 Feb;19(1):60-65.

Clinical Study of Atracurium for Endotracheal Intrbation

• Nam SH
• Bang SO
• Oh HK

Abstract

In order to evaluate the effect on cardiopulmonary fuaction and the relaxation brought about by atracurium elective surgical patients, belonging to ASA class 1 or 2 were anesthetixed with thiopental (5-6mg/kg) and intubated after atracurium injection through a central venous catheter. The changes of blood pressure, heart rate, the degree af relaxation and the time interval between atracurium and intubation were observed. The results are as follows 1) There was an average drop of 20mmHg in the systolic blood pressure and an average rise of 12 beate/min, in the pulse after thiopental (p<0.05), and no more significant changes were observed following atracurium. But significant rises of both were observed after intubation. 2) Following an atracurium injection of 0.62+/-0.01mg/kg, the time interval between atracurium and intubation was 167.78+/-11.15 sec. 3) Vocal cord relaxation was poor in 7 of 9 cases, so intubation was somewhat difficult. From the above results, the effect of atracurium for intubation was not satisfactory in this study. The potency of the atracurium may have changed due to unsuitable preservation at room temperature. Other causes for the lack of relaxation may have been the succesaive injection of thiopental and insufficient doses of atracurium.

MeSH Terms

Atracurium*
Blood Pressure
Central Venous Catheters
Heart Rate
Humans
Intubation
Relaxation
Thiopental
Vocal Cords
Atracurium
Thiopental