J Korean Pediatr Soc.  1981 May;24(5):459-465.

Comparison of Theraputic Effects for Shigellosis Between Rifampin and Other Antimicrobial Agents

• Kim JS
• Kang SW
• Shin KD
• Lee PM

Abstract

A) Bacteriological study and sensitivity test against antimicrobial agents were made on 126 cases of infantile and childhood shigellosis treated at pediatric epartment of St. Vincent hospital from April, 78 to September, 80. The results are follows: 1. Sh. flexneri was most frequently isolated(86.5%) and the next was Sh. sonnei(13.5%). 2. The percentage of resistant strains against antimicrobial agents. Ampicillin: 95.2% Carbenicillin : 90.5% Cephalothin: 78.6% Choloramphenicol: 95.2% Gentamicin: 20.6% Kanamycin: 23.8% Lincomycin: 100% Methicillin: 100% B) The effect of rifampin on bacteriological cure and clinical course in group B shigellosis of sixty-four hospitalized children from one year to five years old age were compared with other antibiotics. gentamicin, ampicillin and trimethoprim-sulfamethoxazole. Based on our study, rifampin was most effective drug in curing of clinical symptoms of shigellosis and eradicating the organisms from stool, and gentamicin was similar effect. Trimethoprim-sulfamethoxazole twas less effective than rifampin and gentamicin, but more effective than ampicillin which has no appreciable effect on the course of shigellosis.

Keyword

Rifampin; Shigellosis; Antimicrobial agents; Therapeutic effects

MeSH Terms

Ampicillin
Anti-Bacterial Agents
Anti-Infective Agents*
Carbenicillin
Cephalothin
Child
Child, Hospitalized
Dysentery, Bacillary*
Gentamicins
Humans
Kanamycin
Lincomycin
Methicillin
Rifampin*
Trimethoprim, Sulfamethoxazole Drug Combination
Ampicillin
Anti-Bacterial Agents
Anti-Infective Agents
Carbenicillin
Cephalothin
Gentamicins
Kanamycin
Lincomycin
Methicillin
Rifampin