Biomol Ther.
2013 Nov;21(6):454-461.
Neuroprotective Effects of a Butanol Fraction of Rosa hybrida Petals in a Middle Cerebral Artery Occlusion Model
- Affiliations
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- 1College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea. solar93@cbu.ac.kr
- 2College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.
- 3Department Food Science and Technology, Chungbuk National University, Cheongju 361-763, Republic of Korea.
- 4Department of Marine Molecular Biotechnology, College of Life Science, Gangneung-Wonju National University, Gangneung 210- 702, Republic of Korea. ssj66@gwnu.ac.kr
Abstract
- The neuroprotective effects of a butanol fraction of white rose petal extract (WRPE-BF) were investigated in a middle cerebral artery occlusion (MCAO) model. Seven week-old male rats were orally administered WRPE-BF for 2 weeks and subjected to MCAO for 2 h, followed by reperfusion. Twenty-four h later, MCAO-induced behavioral dysfunctions were markedly improved in a dose-dependent manner by pretreatment with WRPE-BF. Moreover, higher dose of WRPE-BF not only decreased infarction area but also effectively reduced astrogliosis. The expression of inducible nitric oxide synthase, cyclooxygenase-2, and glial fibrillary acidic protein in MCAO model were markedly inhibited by WRPE-BF treatment. Notably, WRPE-BF decreased nitric oxide and malondialdehyde levels in the striatum and subventricular zone of stroke-challenged brains. These data suggested that WRPE-BF may exert its neuroprotective effects via anti-oxidative and anti-inflammatory activities against ischemia-reperfusion brain injury and could be a good candidate as a therapeutic target for ischemic stroke.
Keyword
MeSH Terms
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Animals
Brain
Brain Injuries
Cyclooxygenase 2
Glial Fibrillary Acidic Protein
Humans
Infarction
Infarction, Middle Cerebral Artery*
Male
Malondialdehyde
Middle Cerebral Artery*
Neuroprotective Agents*
Nitric Oxide
Nitric Oxide Synthase Type II
Rats
Reperfusion
Rosa*
Stroke
Cyclooxygenase 2
Glial Fibrillary Acidic Protein
Malondialdehyde
Neuroprotective Agents
Nitric Oxide
Nitric Oxide Synthase Type II
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