Biomol Ther.  2014 Nov;22(6):477-490. 10.4062/biomolther.2014.105.

Non-Thermal Atmospheric-Pressure Plasma Possible Application in Wound Healing

  • 1Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst-Moritz-Arndt University of Greifswald, D17489 Greifswald, Germany.
  • 2Leibniz Institute of Plasma Science and Technology Greifswald e.V (INP), Felix-Hausdorff Str. 2, 17489 Greifswald, Germany.


Non-thermal atmospheric-pressure plasma, also named cold plasma, is defined as a partly ionized gas. Therefore, it cannot be equated with plasma from blood; it is not biological in nature. Non-thermal atmospheric-pressure plasma is a new innovative approach in medicine not only for the treatment of wounds, but with a wide-range of other applications, as e.g. topical treatment of other skin diseases with microbial involvement or treatment of cancer diseases. This review emphasizes plasma effects on wound healing. Non-thermal atmospheric-pressure plasma can support wound healing by its antiseptic effects, by stimulation of proliferation and migration of wound relating skin cells, by activation or inhibition of integrin receptors on the cell surface or by its pro-angiogenic effect. We summarize the effects of plasma on eukaryotic cells, especially on keratinocytes in terms of viability, proliferation, DNA, adhesion molecules and angiogenesis together with the role of reactive oxygen species and other components of plasma. The outcome of first clinical trials regarding wound healing is pointed out.


Angiogenesis; Cell surface molecules; Cell viability; Non-thermal atmospheric-pressure plasma; Plasma-cell interaction; Reactive oxygen species; Wound healing

MeSH Terms

Cell Survival
Eukaryotic Cells
Plasma Gases
Reactive Oxygen Species
Skin Diseases
Wound Healing*
Wounds and Injuries
Plasma Gases
Reactive Oxygen Species
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