Immune Netw.  2014 Apr;14(2):73-80. 10.4110/in.2014.14.2.73.

Advances in Systems Biology Approaches for Autoimmune Diseases

Affiliations
  • 1Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Seoul 143-729, Korea. ho0919@kuh.ac.kr
  • 2Division of Rheumatology, Department of Internal Medicine, Konkuk University School of Medicine, Seoul 143-729, Korea.

Abstract

Because autoimmune diseases (AIDs) result from a complex combination of genetic and epigenetic factors, as well as an altered immune response to endogenous or exogenous antigens, systems biology approaches have been widely applied. The use of multi-omics approaches, including blood transcriptomics, genomics, epigenetics, proteomics, and metabolomics, not only allow for the discovery of a number of biomarkers but also will provide new directions for further translational AIDs applications. Systems biology approaches rely on high-throughput techniques with data analysis platforms that leverage the assessment of genes, proteins, metabolites, and network analysis of complex biologic or pathways implicated in specific AID conditions. To facilitate the discovery of validated and qualified biomarkers, better-coordinated multi-omics approaches and standardized translational research, in combination with the skills of biologists, clinicians, engineers, and bioinformaticians, are required.

Keyword

Autoimmune diseases; Systems biology; Multi-omics; Biomarker; Translational research; Network analysis

MeSH Terms

Autoimmune Diseases*
Biomarkers
Epigenomics
Genomics
Metabolomics
Proteomics
Statistics as Topic
Systems Biology*
Translational Medical Research
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