- Systems Bioinformatics Research Trends
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Lee E, Lee D
- KMID: 2330857
- J Korean Soc Med Inform.
- 2008 Dec;14(4):313-327.
Bioinformatics is the information technology to deal with biological data. Recently emerging systems biology has drawn great interest inspired by world-wide efforts for modeling and analyzing biological processes with a... -
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- Systems Biology-Based Platforms to Accelerate Research of Emerging Infectious Diseases
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Oh SJ, Choi YK, Shin OS
- KMID: 2418779
- Yonsei Med J.
- 2018 Mar;59(2):176-186.
- doi: 10.3349/ymj.2018.59.2.176
Emerging infectious diseases (EIDs) pose a major threat to public health and security. Given the dynamic nature and significant impact of EIDs, the most effective way to prevent and protect... -
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- Systems Approach to Rheumatoid Arthritis
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Kim KJ, Hwang D, Kim WU
- KMID: 2222992
- J Rheum Dis.
- 2013 Dec;20(6):348-355.
- doi: 10.4078/jrd.2013.20.6.348
Phenotypic characteristics of complex diseases such as rheumatoid arthritis are a consequence of interactions of genetic and environmental factors. Biomolecules closely interact with other molecular components and form functional modules,... -
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- Systems biology approaches in asthma pharmacogenomics study
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Park HW
- KMID: 1803538
- Allergy Asthma Respir Dis.
- 2014 Nov;2(5):326-331.
- doi: 10.4168/aard.2014.2.5.326
The response to drug treatment in asthma is a complex trait and is markedly variable even in patients with apparently similar clinical features. Pharmacogenomics is a study of variations of... -
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- Java DOM Parsers to Convert KGML into SBML and BioPAX Common Exchange Formats
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Lee KE, Jang MH, Rhie A, Thong CT, Yang S, Park HS
- KMID: 2166485
- Genomics Inform.
- 2010 Jun;8(2):94-96.
Integrating various pathway data collections to create new biological knowledge is a challenge, for which novel computational tools play a key role. For this purpose, we developed the Java-based conversion... -
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- Advances in Systems Biology Approaches for Autoimmune Diseases
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Kim HY, Kim HR, Lee SH
- KMID: 2168017
- Immune Netw.
- 2014 Apr;14(2):73-80.
- doi: 10.4110/in.2014.14.2.73
Because autoimmune diseases (AIDs) result from a complex combination of genetic and epigenetic factors, as well as an altered immune response to endogenous or exogenous antigens, systems biology approaches have... -
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- An Information-based Model for an Interactive Web Service with Agricultural Biotechnology
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Kim CK, Seol YJ, Park DS, Hahn JH
- KMID: 2053268
- Genomics Inform.
- 2011 Jun;9(2):85-88.
The National Agricultural Biotechnology Information Center (NABIC) constructed an agricultural biology-based infrastructure and developed a biological information-based database. The major functions of the NABIC are focused on biotechnological developments for... -
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- Systems Biology Approaches to Decoding the Genome of Liver Cancer
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Lee JS, Kim JH, Park YY, Mills GB
- KMID: 2167561
- Cancer Res Treat.
- 2011 Dec;43(4):205-211.
Molecular classification of cancers has been significantly improved patient outcomes through the implementation of treatment protocols tailored to the abnormalities present in each patient's cancer cells. Breast cancer represents the... -
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- Applications of systems approaches in the study of rheumatic diseases
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Kim KJ, Lee S, Kim WU
- KMID: 2160677
- Korean J Intern Med.
- 2015 Mar;30(2):148-160.
- doi: 10.3904/kjim.2015.30.2.148
The complex interaction of molecules within a biological system constitutes a functional module. These modules are then acted upon by both internal and external factors, such as genetic and environmental... -
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- Parsing KEGG XML Files to Find Shared and Duplicate Compounds Contained in Metabolic Pathway Maps: A Graph-Theoretical Perspective
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Kang SH, Jang MH, Whang J, Park HS
- KMID: 2166412
- Genomics Inform.
- 2008 Sep;6(3):147-152.
The basic graph layout technique, one of many visualization techniques, deals with the problem of positioning vertices in a way to maximize some measure of desirability in a graph. The... -
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- A Computer-aided Design Tool with Semiautomatic Image-Processing Features for Visualizing Biological Pathways
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Ham SI, Yang SD, Thong CT, Park HS
- KMID: 1469577
- Genomics Inform.
- 2009 Sep;7(3):168-170.
The explosion in biological data resulting from highthroughput experiments requires new software tools to manipulate and display pathways in a way that can integrate disparate sources of information. A visual... -
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- Microarray Data Analysis of Perturbed Pathways in Breast Cancer Tissues
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Kim C, Choi J, Yoon S
- KMID: 2166421
- Genomics Inform.
- 2008 Dec;6(4):210-222.
Due to the polygenic nature of cancer, it is believed that breast cancer is caused by the perturbation of multiple genes and their complex interactions, which contribute to the wide... -
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- TarGo: network based target gene selection system for human disease related mouse models
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Hyung D, Mallon AM, Kyung DS, Cho SY, Seong JK
- KMID: 2470013
- Lab Anim Res.
- 2019 Dec;35(4):165-171.
- doi: 10.1186/s42826-019-0023-z
Genetically engineered mouse models are used in high-throughput phenotyping screens to understand genotype-phenotype associations and their relevance to human diseases. However, not all mutant mouse lines with detectable phenotypes are... -
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- Big Data Analysis Using Modern Statistical and Machine Learning Methods in Medicine
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Yoo C, Ramirez L, Liuzzi J
- KMID: 2232924
- Int Neurourol J.
- 2014 Jun;18(2):50-57.
In this article we introduce modern statistical machine learning and bioinformatics approaches that have been used in learning statistical relationships from big data in medicine and behavioral science that typically... -
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- Comparative Analyses of Signature Genes in Acute Rejection and Operational Tolerance
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Choi JW, Kim YH, Oh JW
- KMID: 2388078
- Immune Netw.
- 2017 Aug;17(4):237-249.
- doi: 10.4110/in.2017.17.4.237
Using biomarkers as prediction tools or therapeutic targets can be a valuable strategy in transplantation. Recent studies identified biomarkers of acute rejection (AR) and operational tolerance (TOL) through the application... -
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- Integrative Analysis of Microarray Data with Gene Ontology to Select Perturbed Molecular Functions using Gene Ontology Functional Code
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Kim C, Choi J, Yoon S
- KMID: 2053231
- Genomics Inform.
- 2009 Jun;7(2):122-130.
A systems biology approach for the identification of perturbed molecular functions is required to understand the complex progressive disease such as breast cancer. In this study, we analyze the microarray... -
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- Polyionic vaccine adjuvants: another look at aluminum salts and polyelectrolytes
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Powell BS, Andrianov , Fusco PC
- KMID: 2049105
- Clin Exp Vaccine Res.
- 2015 Jan;4(1):23-45.
- doi: 10.7774/cevr.2015.4.1.23
Adjuvants improve the adaptive immune response to a vaccine antigen by modulating innate immunity or facilitating transport and presentation. The selection of an appropriate adjuvant has become vital as new... -
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