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Isolation of Small Extracellular Vesicles From Human Serum Using a Combination of Ultracentrifugation With Polymer-Based Precipitation

Ryu KJ, Lee JY, Park C, Cho D, Kim SJ

Methods for reproducibly isolating and enriching small extracellular vesicles (EVs) from blood are essential for clinical utilization of small EVs in cancer patients. We combined ultracentrifugation (UC) with polymer-based precipitation...
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Bibliometric analysis of studies about acute myeloid leukemia conducted globally from 1999 to 2018

Seo B, Kim J, Kim S, Lee E

A bibliometric study is performed to analyze publication patterns in a specific research area and to establish a landscape model that can be used to quantitatively weigh publications. This study...
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Human Neural Stem Cells: Translational Research for Neonatal Hypoxic-Ischemic Brain Injury

Shin JE, Han J, Lim JH, Eun HS, Park KI

Neonatal hypoxic-ischemic (HI) brain injury is a major cause of neonatal mortality and long-term neurodevelopmental disabilities. Although promising neuroprotective interventions have been studied, the current management of HI brain injury...
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Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research

Atkinson A

In the conventional concept of translational research, investigations flow from the laboratory bench to the bedside. However, clinical research can also serve as the starting point for subsequent laboratory investigations...
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Novel Biomarkers for Prediction of Response to Preoperative Systemic Therapies in Gastric Cancer

Cavaliere , Merz V, Casalino S, Zecchetto , Simionato , Salt HL, Contarelli S, Santoro R, Melisi D

Preoperative chemo- and radiotherapeutic strategies followed by surgery are currently a standard approach for treating locally advanced gastric and esophagogastric junction cancer in Western countries. However, in a large number...
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Management and prevention of third molar surgery-related trigeminal nerve injury: time for a rethink

Leung YY

Trigeminal nerve injury as a consequence of lower third molar surgery is a notorious complication and may affect the patient in long term. Inferior alveolar nerve (IAN) and lingual nerve...
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Developing a core competency model for translational medicine curriculum

Yoon HB, Park DJ, Shin JS, Ahn C

PURPOSE: This study aimed to develop a core competency model for translational medicine curriculum in the Korean graduate education context. METHODS: We invited specialists and key stakeholders to develop a consensus...
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Current Issues of Healthcare Research and Development in Korea

Kim K

There has been much efforts to facilitate healthcare innovation and many desirable outcomes were produced in Korea. However, some structural deficiencies were found. They are misalignment of research and development...
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Review of the UBC Porcine Model of Traumatic Spinal Cord Injury

Kim KT, Streijger , Manouchehri N, So K, Shortt K, Okon EB, Tigchelaar S, Cripton P, Kwon BK

Traumatic spinal cord injury (SCI) research has recently focused on the use of rat and mouse models for in vivo SCI experiments. Such small rodent SCI models are invaluable for...
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Choice of Rods in Surgical Treatment of Adolescent Idiopathic Scoliosis: What Are the Clinical Implications of Biomechanical Properties? – A Review of the Literature

Ohrt-Nissen S, Dahl B, Gehrchen M

The surgical treatment of adolescent idiopathic scoliosis (AIS) involves 3-dimensional curve correction with multisegmental pedicle screws attached to contoured bilateral rods. The substantial corrective forces exert a high level of...
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Let Archived Paraffin Blocks Be Utilized for Research with Waiver of Informed Consent

Kim YJ, Park JS, Ko K, Jeong CR

Advances in biomedical and genetic research have contributed to more effective public health improvement via bench-to-bed research and the emergence of personalized medicine. This has certainly showcased the importance of...
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Induction of Rhesus Keratinocytes into Functional Ameloblasts by Mouse Embryonic Dental Mesenchyme

Ruan N, Lin C, Dong X, Hu X, Zhang Y

Fast progresses in stem cell-based tooth tissue engineering have been achieved in recent years in several animal models including the mouse, rat, dog, and pig. Moreover, various postnatal mesenchymal stem...
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Extracellular Vesicles in Psychiatry Research in the Context of RDoC Criteria

Ilgın C, Topuzoğlu A

The analysis of extracellular vesicles has been accelerated because of the technological advancements in omics methods in recent decades. Extracellular vesicles provide multifaceted information regarding the functional status of the...
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Epileptic Spasms, a Journey to Find Therapeutics Based on Pathophysiology

Yum MS

After the first description of infantile spasms (IS) in 1841, extensive clinical and laboratory investigations have been done to find the pathophysiology and the optimal treatments. The concept of the...
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Allergic conjunctivitis in Asia

Thong BY

Allergic conjunctivitis (AC), which may be acute or chronic, is associated with rhinitis in 30%–70% of affected individuals, hence the term allergic rhinoconjunctivitis (AR/C). Seasonal and perennial AC is generally...
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Patient-Derived Xenograft Models of Epithelial Ovarian Cancer for Preclinical Studies

Heo EJ, Cho YJ, Cho WC, Hong JE, Jeon HK, Oh DY, Choi YL, Song SY, Choi JJ, Bae DS, Lee YY, Choi CH, Kim TJ, Park WY, Kim BG, Lee JW

PURPOSE: Patient-derived tumor xenografts (PDXs) can provide more reliable information about tumor biology than cell line models. We developed PDXs for epithelial ovarian cancer (EOC) that have histopathologic and genetic...
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History of the Official Journal Published by the Korean Society of Pathologists: From the Korean Journal of Pathology to the Journal of Pathology and Translational Medicine

Kim SH, Kim CJ, Hong S

No abstract available.
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Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study

Cho CH, Ahn YM, Kim SJ, Ha TH, Jeon HJ, Cha B, Moon E, Park DY, Baek JH, Kang HJ, Ryu V, An H, Lee HJ

The Mood Disorder Cohort Research Consortium (MDCRC) study is designed as a naturalistic observational prospective cohort study for early-onset mood disorders (major depressive disorders, bipolar disorders type 1 and 2)...
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Immunotherapy for human papillomavirus-associated disease and cervical cancer: review of clinical and translational research

Lee SJ, Yang A, Wu TC, Hung CF

Cervical cancer is the fourth most lethal women's cancer worldwide. Current treatments against cervical cancer include surgery, radiotherapy, chemotherapy, and anti-angiogenic agents. However, despite the various treatments utilized for the...
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Current Status of Translational Research on Constipation

Lee HJ, Park KS

Constipation is one of the most common gastrointestinal disorders with a prevalence up to 16.5% in the general population. It is frequently multifactorial and the pathophysiologic mechanism of constipation is...
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