J Korean Soc Endocrinol.  2006 Jun;21(3):184-188. 10.3803/jkes.2006.21.3.184.

Translational Research Using Sodium/Iodide Symporter

• Chung JK
• Kang JH

• KMID: 2200729
• DOI: http://doi.org/10.3803/jkes.2006.21.3.184

Abstract

No abstract available.

MeSH Terms

Ion Transport*
Translational Medical Research*

Figure

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  Fig. 1 Comparison of I-131 therapy result according to NIS expression in tumor tissue.

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  Fig. 2 Survival rate of human hepatoma cells (SK-Hep-1) and NIS transfected hepatoma cells (SK-Hep-1-NIS) after incubation with I-131 and Re-188.

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  Fig. 3 Tc-99m Scintigraphy in a nude mouse bearing human hepatoma (SK-Hep1) and hepatomas containing p53NIS (SK-Hep1p53NIS) before and after adriamycin treatment. Before adriamycin treatment, there was no uptake of Tc-99m in the control tumor (A) and faint uptake in test tumors (B-D) due to natural expression of endogenous p53. After adriamycin treatment, increased uptake of Tc-99m was noted in test tumors (B-D) due to increased expression of endogenous p53 gene without any change in the control tumor (A). A, 1 × 107 SK-Hep1 cells (negatve control); B, 5 × 106 SK-Hep1-p53NIS cells; C, 1 × 107 SK-Hep1-p53NIS cells; D, 2 × 107 SK-Hep1-p53NIS cells.

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