Biomol Ther.  2016 May;24(3):305-311. 10.4062/biomolther.2015.131.

Mitochondria-Targeted Vitamin E Protects Skin from UVB-Irradiation

• Kim WS
• Kim I
• Kim WK
• Choi JY
• Kim DY
• Moon SG
• Min HK
• Song MK
• Sung JH

• KMID: 2164223
• DOI: http://doi.org/10.4062/biomolther.2015.131

Abstract

Mitochondria-targeted vitamin E (MVE) is designed to accumulate within mitochondria and is applied to decrease mitochondrial oxidative damage. However, the protective effects of MVE in skin cells have not been identified. We investigated the protective effect of MVE against UVB in dermal fibroblasts and immortalized human keratinocyte cell line (HaCaT). In addition, we studied the wound-healing effect of MVE in animal models. We found that MVE increased the proliferation and survival of fibroblasts at low concentration (i.e., nM ranges). In addition, MVE increased collagen production and downregulated matrix metalloproteinase1. MVE also increased the proliferation and survival of HaCaT cells. UVB increased reactive oxygen species (ROS) production in fibroblasts and HaCaT cells, while MVE decreased ROS production at low concentration. In an animal experiment, MVE accelerated wound healing from laser-induced skin damage. These results collectively suggest that low dose MVE protects skin from UVB irradiation. Therefore, MVE can be developed as a cosmetic raw material.

Keyword

Mitochondria-Targeted vitamin E; UVB protection; Fibroblast; HaCaT; Collagen

MeSH Terms

Animal Experimentation
Cell Line
Collagen
Fibroblasts
Humans
Keratinocytes
Mitochondria
Models, Animal
Reactive Oxygen Species
Skin*
Vitamin E*
Vitamins*
Wound Healing
Collagen
Reactive Oxygen Species
Vitamin E
Vitamins