Ann Dermatol.
2001 Sep;13(3):133-138. 10.5021/ad.2001.13.3.133.
Translocation of p53 Protein in Melanocytes and Malignant Melanoma Cells After UVB Irradiation
- KMID: 2163881
- DOI: http://doi.org/10.5021/ad.2001.13.3.133
Abstract
- BACKGROUND
UVB is responsible for most of the carcinogenic effects of sun exposure.
OBJECTIVE
Aim of this study was to investigate the regulation and intracellular redistribution of p53 protein after UVB irradiation.
METHODS
Cultured normal human melanocytes and G361 melanoma cells were used for west-ern blotting and confocal microscopic examination for determining expression and distribution of p53.
RESULTS
UVB irradiation increased p53 expression in cultured normal human melanocytes and G361 malignant melanoma cells according to increasing doses of UVB. Furthermore, p53 moved from cytosol to nucleus after UVB irradiation.
CONCLUSIONS
UVB irradiation induced overexpression and redistribution of p53 in cultured normal human melanocytes and G361 malignant melanoma cells.
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