Int J Stem Cells.  2016 May;9(1):96-106. 10.15283/ijsc.2016.9.1.96.

Therapeutic Potential of Bone Marrow-Derived Mesenchymal Stem Cells on Experimental Liver Injury Induced by Schistosoma mansoni: A Histological Study

Affiliations
  • 1Department of Histology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. walaabaher78@gmail.com

Abstract

BACKGROUND AND OBJECTIVES
Bone marrow derived mesenchymal stem cells (BM-MSCs) have been proposed as effective treatment of many diseases owing to their unique ability to differentiate into other cell types in vivo. Schistosoma mansoni (S. mansoni) infection is characterized by hepatic granuloma formation around schistosome eggs at acute stage of infection, followed by hepatic fibrosis at chronic and advanced stages. Whether BM-MSCs have an ameliorative effect on hepatic tissue injury caused by S. mansoni infection or not, was inspected in the current study. MATERIALS AND RESULTS: Female Swiss Albino mice were divided into a control group and an experimental group. Half of control animals served as donors for bone marrow stem cells, and the other half was used to collect liver samples. Experimental group was injected with circariae of S. mansoni, and then subdivided into three subgroups; Subgroup B1, sacrificed after eight weeks of infection without treatment, subgroup B2, received BM-MSCs at the eighth week and sacrificed four weeks later, and subgroup B3, was untreated till the twelfth week of infection. Histological examination of liver samples showed the formation of granulomas and liver fibrosis which were extensive in subgroup B3. However, treated subgroup illustrated improvement of liver histology, signs of hepatocytes regeneration, and possible contribution of oval cell in the process of hepatic and biliary regeneration.
CONCLUSION
BM-MSCs decreased liver fibrosis and contributed to an increase in oval cells, generation of new hepatocytes and/or to the improvement of resident hepatocytes in S. mansoni infected mice.

Keyword

S. mansoni; Mesenchymal stem cells; Liver fibrosis; Oval cells

MeSH Terms

Animals
Bone Marrow
Eggs
Female
Fibrosis
Granuloma
Hepatocytes
Humans
Liver Cirrhosis
Liver*
Mesenchymal Stromal Cells*
Mice
Ovum
Regeneration
Schistosoma mansoni*
Schistosoma*
Stem Cells
Tissue Donors
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