Immune Netw.  2003 Jun;3(2):156-163. 10.4110/in.2003.3.2.156.

Immune Stimulating Efficacy of Soluble beta-1,3-glucans

• Shim JH
• Choi WA
• Kim JW
• Lee HS
• Baek TW
• Cho MC
• Lee KA
• Sang BC
• Yoon DY

• KMID: 2150582
• DOI: http://doi.org/10.4110/in.2003.3.2.156

Abstract

BACKGROUND
beta-1,3-glucans are well known to enhance the immune reactions, resulting in antitumor, antibacterial, antiviral, anticoagulatory and wound healing activities. beta-1, 3-glucans have various activities depending on molecular weight, degree of branching, conformation, water-solubility and intermolecular association. However, the beta-1,3-glucan linked backbone structure is essential and beta-D-glucopyranosyl units are required for immuno-potentiating activities. RESULT: In this study, we tested the immunophamacological activities of soluble beta-1,3-glucans and confirmed the following activities: (1) IFN-gamma production in PBMCs in the presence or the absence of PHA, LPS, or IL-18; (2) induction of various cytokines in the spleen and thymus; (3) adjuvant effect on the antibody production; (4) nitrogen oxide synthesis in macrophages; (5) the cytotoxic and antitumor effects on cell lines and ICR mice. CONCLUSION: These results strongly suggested that beta-1,3-glucans possessed various immuno-pharmacological activities

Keyword

Soluble beta-1; 3-glucan; immunophamacological activities; antitumor effect

MeSH Terms

Animals
Antibody Formation
Cell Line
Cytokines
Interleukin-18
Macrophages
Mice
Mice, Inbred ICR
Molecular Weight
Nitrogen
Spleen
Thymus Gland
Wound Healing
Cytokines
Interleukin-18
Nitrogen