J Vet Sci.  2015 Dec;16(4):389-396. 10.4142/jvs.2015.16.4.389.

Anti-adipogenic effect of Artemisia annua in diet-induced-obesity mice model

Affiliations
  • 1Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University, Asan 31538, Korea. admiral96@sch.ac.kr
  • 2Department of Medical Biotechnology, College of Medical Sciences, Soonchunhyang University, Asan 31538, Korea.
  • 3Department of Life Science and Biotechnology, College of Natural Sciences, Soonchunhyang University, Asan 31538, Korea.
  • 4Genomic Informatic Center, Han-kyong National University, Anseong 17579, Korea.
  • 5Department of Biotechnology, Hoseo University, Asan 31499, Korea.

Abstract

Obesity has increased continuously in western countries during the last several decades and recently become a problem in developing countries. Currently, anti-obesity drugs originating from natural products are being investigated for their potential to overcome adverse effects associated with chemical drugs. Artemisinic acid, which was isolated from the well-known anti-malaria herb Artemisia annua (AA) L., was recently shown to possess anti-adipogenic effects in vitro. However, the anti-adipogenic effects of AA in animal models have not yet been investigated. Therefore, we conducted daily oral administration with AA water extract in a diet-induced obesity animal model and treated 3T3-L1 cells with AA to confirm the anti-adipogenic effects in the related protein expressions. We then evaluated the physiology, adipose tissue histology and mRNA expressions of many related genes. Inhibition of adipogenesis by the AA water extract was observed in vitro. In the animal model, weight gain was significantly lower in the AA treated group, but there were no changes in food intake volume or calories. Reductions in lipid droplet size and mRNA expression associated with adipogenesis were also observed in animal epididymal fat. This study is the first to report that AA has an anti-obese effects in vivo.

Keyword

adipogenesis; animal model; Artemisia annua; diet induced obesity; obesity

MeSH Terms

3T3-L1 Cells
Adipogenesis
Adipose Tissue
Administration, Oral
Animals
Anti-Obesity Agents
Artemisia annua*
Artemisia*
Biological Products
Developing Countries
Eating
Mice*
Models, Animal
Obesity
Physiology
RNA, Messenger
Water
Weight Gain
Anti-Obesity Agents
Biological Products
RNA, Messenger
Water
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