J Korean Med Sci.  2014 Aug;29(8):1178-1181. 10.3346/jkms.2014.29.8.1178.

Susceptibility of Escherichia coli from Community-Acquired Urinary Tract Infection to Fosfomycin, Nitrofurantoin, and Temocillin in Korea

  • 1Division of Infectious Diseases, Department of Internal Medicine, Hanyang University, Seoul, Korea. paihyunjoo@gmail.com
  • 2Department of Laboratory Medicine, Hanyang University, Seoul, Korea.
  • 3Department of Clinical Microbiology, Hanyang University, Guri, Korea.
  • 4Department of Internal Medicine, St. Vincent's Hospital, School of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 5Department of Preventive Medicine, Eulji University School of Medicine, Daejeon, Korea.
  • 6Department of Internal Medicine, Gil Hospital, Gacheon University, Incheon, Korea.
  • 7Department of Internal Medicine, Ajou University Hospital, Suwon, Korea.
  • 8Department of Internal Medicine, Hallym University, Kangdong Sacred Heart Hospital, Seoul, Korea.
  • 9Department of Internal Medicine, Daegu Patima Hospital, Daegu, Korea.
  • 10Department of Internal Medicine, Dong-A University Hospital, Busan, Korea.
  • 11Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.
  • 12Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea.
  • 13Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
  • 14Department of Internal Medicine, Inha University Hospital, Incheon, Korea.


With increase of multi-drug resistant Escherichia coli in community-acquired urinary tract infections (CA-UTI), other treatment option with a therapeutic efficacy and a low antibiotic selective pressure is necessary. In this study, we evaluated in vitro susceptibility of E. coli isolates from CA-UTI to fosfomycin (FM), nitrofurantoin (NI), temocillin (TMO) as well as trimethoprim-sulfamethoxazole (SMX), ciprofloxacin (CIP) and cefepime (FEP). The minimal inhibitory concentrations were determined by E-test or agar dilution method according to the Clinical and Laboratory Standards Institute guidelines, using 346 E. coli collected in 12 Korean hospitals from March 2010 to February 2011. FM, NI and TMO showed an excellent susceptibility profile; FM 100% (346/346), TMO 96.8% (335/346), and NI 99.4% (344/346). Conversely, resistance rates of CIP and SMX were 22% (76/346) and 29.2% (101/349), respectively. FEP still retained an activity of 98.5%. In Korea, NI and TMO in addition to FM are a good therapeutic option for uncomplicated CA-UTI, especially for lower UTI.


Community-Acquired Infections; Urinary Tract; Escherichia coli; Fosfomycin; Nitrofurantoin; Temocillin; Trimethoprim-Sulfamethoxazole combination; Ciprofloxacin; Cefepime; Minimal Inhibitory Concentration

MeSH Terms

Anti-Bacterial Agents/*administration & dosage
Cell Survival/*drug effects
Cephalosporins/administration & dosage
Ciprofloxacin/administration & dosage
Community-Acquired Infections/drug therapy/*microbiology
Dose-Response Relationship, Drug
Drug Combinations
Drug Resistance, Bacterial/drug effects
Escherichia coli/*drug effects
Escherichia coli Infections/drug therapy/*microbiology
Fosfomycin/administration & dosage
Nitrofurantoin/administration & dosage
Penicillins/administration & dosage
Republic of Korea
Sulfadoxine/administration & dosage
Treatment Outcome
Trimethoprim/administration & dosage
Urinary Tract Infections/diagnosis/*microbiology
Anti-Bacterial Agents
Drug Combinations
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