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Comparison of Two Combinations of Maximum Medical Therapy for Lowering Intraocular Pressure in Primary Open-angle Glaucoma

Wy S, Kim YK, Jeoung JW, Park KH, Ha A

PURPOSE: We sought to compare the efficacy as well as the safety of two maximum medical therapy combinations applied to lower the intraocular pressure (IOP) in different primary open-angle glaucoma...
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Ethanol extract of Allium fistulosum inhibits development of non-alcoholic fatty liver disease

Hwang JT, Shin EJ, Chung MY, Park JH, Chung S, Choi HK

BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is closely associated with metabolic syndrome. In the present study, we observed the effect of...
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Emerging Therapies: What Are Promising in the Near Future?

Seo GS, Lee SH

The treatment of inflammatory bowel disease has evolved with the development of anti-TNF agents. In spite of long-term effectiveness, many patients do not respond or no longer responds to these...
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Combinatorial Antitumor Activity of Oxaliplatin with Epigenetic Modifying Agents, 5-Aza-CdR and FK228, in Human Gastric Cancer Cells

Park JK, Seo JS, Lee SK, Chan KK, Kuh HJ

Epigenetic silencing is considered to be a major mechanism for loss of activity in tumor suppressors. Reversal of epigenetic silencing by using inhibitors of DNA methyltransferase (DNMT) or histone deacetylases...
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Combination of berberine and ciprofloxacin reduces multi-resistant Salmonella strain biofilm formation by depressing mRNA expressions of luxS, rpoE, and ompR

Shi C, Li M, Muhammad I, Ma X, Chang Y, Li R, Li C, He J, Liu F

Bacterial biofilms have been demonstrated to be closely related to clinical infections and contribute to drug resistance. Berberine, which is the main component of Coptis chinensis, has been reported to...
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Serotonin Syndrome following Duloxetine Administration in a Fibromyalgia Patient: Case Report and Literature Review

Choi JS, Lee JH, Park SK, Shim BJ, Choi WK, Kim SH, Hwang SC

Serotonin syndrome, an adverse drug reaction, is a consequence of excess serotonergic agonism of central nervous system receptors and peripheral serotonergic receptors. Serotonin syndrome has been associated with large numbers...
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A review on prescribing patterns of antihypertensive drugs

Jarari N, Rao N, Peela JR, Ellafi KA, Shakila S, Said AR, Nelapalli , Min Y, Tun KD, Jamallulail SI, Rawal AK, Ramanujam , Yedla RN, Kandregula DK, Argi A, Peela LT

Hypertension continues to be an important public health concern because of its associated morbidity, mortality and economic impact on the society. It is a significant risk factor for cardiovascular, cerebrovascular...
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Efficacy of Magnesium Trihydrate of Ursodeoxycholic Acid and Chenodeoxycholic Acid for Gallstone Dissolution: A Prospective Multicenter Trial

Hyun JJ, Lee HS, Kim CD, Dong SH, Lee SO, Ryu JK, Lee DH, Jeong S, Kim TN, Lee J, Koh DH, Park ET, Lee I, Yoo BM, Kim JH

BACKGROUND/AIMS: Cholecystectomy is necessary for the treatment of symptomatic or complicated gallbladder (GB) stones, but oral litholysis with bile acids is an attractive alternative therapeutic option for asymptomatic or mildly...
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Sodium Picosulfate with Magnesium Citrate (SPMC) Plus Laxative Is a Good Alternative to Conventional Large Volume Polyethylene Glycol in Bowel Preparation: A Multicenter Randomized Single-Blinded Trial

Kim HG, Huh KC, Koo HS, Kim SE, Kim JO, Kim TI, Kim HS, Myung SJ, Park DI, Shin JE, Yang DH, Lee SH, Lee JS, Lee CK, Chang DK, Joo YE, Cha JM, Hong SP, Kim HJ

BACKGROUND/AIMS: We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety. METHODS: We performed...
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Efficacy of the Mineral Oil and Hyaluronic Acid Mixture Eye Drops in Murine Dry Eye

Choi JH, Kim JH, Li Z, Oh HJ, Ahn KY, Yoon KC

PURPOSE: To investigate the therapeutic effects of mineral oil (MO) and hyaluronic acid (HA) mixture eye drops on the tear film and ocular surface in a mouse model of experimental...
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Dystonia in an Adolescent on Risperidone Following the Discontinuation of Methylphenidate: A Case Report

Guler G, Yildirim V, Kutuk MO, Toros F

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with common comorbidities that include oppositional defiant disorder, conduct disorder, anxiety disorder, and affective disorders. Because of these comorbidities, drug combination treatments and...
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Treatment of Neisseria gonorrhoeae in the Era of Multidrug Resistance

Chae JY, Oh MM

Neisseria gonorrhoeae (NG) is becoming increasingly less susceptible to the extended spectrum cephalosporin (ESC), which has been recommended for first-line treatment, and cases of treatment failure are being reported globally....
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Minimal Stimulation Using Gonadotropin Combined with Clomiphene Citrate or Letrozole for Intrauterine Insemination

Yun BH, Chon SJ, Park JH, Seo SK, Cho S, Choi YS, Kim SH, Lee BS

PURPOSE: To evaluate the efficacy of minimal stimulation using discretely administered gonadotropin combined with clomiphene citrate (CC) or letrozole (LTZ) for intrauterine insemination (IUI) cycles. MATERIALS AND METHODS: Total 257 IUI...
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Sympathetic Ophthalmia after Ocular Wasp Sting

Im JC, Kang YK, Park TI, Shin JP, Kim HK

No abstract available.
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Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines

Avila-Arroyo S, Nunez GS, Garcia-Fernandez LF, Galmarini

PURPOSE: Trabectedin induces synthetic lethality in tumor cells carrying defects in homologous recombinant DNA repair. We evaluated the effect of concomitant inhibition of nucleotide-excision repair and poly (ADP-ribose) polymerase (PARP)...
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Comparison of Cytotoxic Effects on Rabbit Corneal Endothelium between Preservative-free and Preservative-containing Dorzolamide/timolol

Kwon J, Heo JH, Kim HM, Song JS

PURPOSE: To evaluate and compare the toxic effects of eyedrops containing a fixed combination of 2.0% dorzolamide and 0.5% maleate timolol with or without preservatives on rabbit corneal endothelium. METHODS: This...
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Susceptibility of Escherichia coli from Community-Acquired Urinary Tract Infection to Fosfomycin, Nitrofurantoin, and Temocillin in Korea

Seo MR, Kim SJ, Kim Y, Kim J, Choi TY, Kang JO, Wie SH, Ki M, Cho YK, Lim SK, Lee JS, Kwon KT, Lee H, Cheong HJ, Park DW, Ryu SY, Chung MH, Pai H

With increase of multi-drug resistant Escherichia coli in community-acquired urinary tract infections (CA-UTI), other treatment option with a therapeutic efficacy and a low antibiotic selective pressure is necessary. In this...
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Antihyperglycemic agent combination therapy for patients with type 2 diabetes mellitus

Lee JM

Type 2 diabetes mellitus and diabetic complications have sharply increased and have become an important issue to resolve. The goal of treatment of type 2 diabetes is to prevent the...
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Visceral Leishmaniasis without Fever in an 11-Month-Old Infant: a Rare Clinical Feature of Kala-azar

Sayyahfar , Ansari S, Mohebali M, Behnam B

  • KMID: 1792167
  • Korean J Parasitol.
  • 2014 Apr;52(2):189-191.
Visceral leishmaniasis or kala-azar is an endemic parasitic disease in some parts of the world which is characterized by fever, splenomegaly, and pancytopenia in most of the cases. Herein we...
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Antihypertensive drug combinations

Park JB

Hypertension has a diverse pathophysiology. Theoretically, one drug is not sufficient to control high blood pressure (BP) in most hypertension. Therefore, the combination of two or more drugs with different...
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