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Pharmacogenomics in Drug Discovery and Development

Ahn C

  • KMID: 2166254
  • Genomics Inform.
  • 2007 Jun;5(2):41-45.
Pharmacogenomics is the study that examines how genetic variations affect the ways in which people respond to drugs. The ways people respond to drugs are complex traits that are influenced...
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Antihypertensive drug combinations

Park JB

Hypertension has a diverse pathophysiology. Theoretically, one drug is not sufficient to control high blood pressure (BP) in most hypertension. Therefore, the combination of two or more drugs with different...
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Treatment of Neisseria gonorrhoeae in the Era of Multidrug Resistance

Chae JY, Oh MM

Neisseria gonorrhoeae (NG) is becoming increasingly less susceptible to the extended spectrum cephalosporin (ESC), which has been recommended for first-line treatment, and cases of treatment failure are being reported globally....
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Drug interaction: focusing on response surface models

Lee SI

Anesthesiologists have been aware of the importance of optimal drug combination long ago and performed many investigations about the combined use of anesthetic agents. There are 3 classes of drug...
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Dystonia in an Adolescent on Risperidone Following the Discontinuation of Methylphenidate: A Case Report

Guler G, Yildirim V, Kutuk MO, Toros F

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with common comorbidities that include oppositional defiant disorder, conduct disorder, anxiety disorder, and affective disorders. Because of these comorbidities, drug combination treatments and...
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Enhancement of Cytotoxicity by the Combination of Anticancer Drugs in Human Lung Adenocarcinoma Cell Line (PC-14)

Lee CT

  • KMID: 2318032
  • Tuberc Respir Dis.
  • 1997 Jun;44(3):525-533.
BACKGROUND: No ideal combination chemotherapy for lung cancer has been established even though lots of combination anticancer chemotherapies have been tried. For the combination of anticancer drugs, the interaction of...
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Fatal Renal Bleeding in a Patient Treated With Aggressive Antithrombotic Therapy After Recurrent Coronary Stent Thrombosis

Moon J, Lee SH, Yang WI, Ko YG, Han WK, Jang Y

Triple antiplatelet therapy has been known to be superior to the conventional dual regimen for preventing stent thrombosis after coronary stenting, and the addition of oral anticoagulation to antiplatelet therapy...
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Identification of ACT-1 Plasmid-Mediated AmpC beta-Lactamase Producing Citrobacter freundii from a Chinese Patient

Wei Y, Wang J

No abstract available.
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Drug Therapy for Obesity

Kim KS, Park SW

  • KMID: 2270999
  • Korean J Obes.
  • 2012 Dec;21(4):197-202.
Obesity is associated with a substantial increase in metabolic disorders and various cancers. As weight loss achieved with lifestyle intervention is modest, there is a need for drug treatment. Orlistat, phentermine,...
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Chemical Composition and Antimicrobial Activity of the Essential Oil of Chrysanthemum indicum Against Oral Bacteria

Jung EK

The chemical components of the essential oil obtained from Chrysanthemum indicum L. were analyzed by GC-MS. Seventy-three compounds accounting for 96.65% of the extracted essential oil were identified. The main...
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Co-prescribing Patterns of Contraindicated Drugs for the Elderly Patients in Busan

Choi NK, Jung SY, Park BJ

  • KMID: 2233459
  • Korean J Epidemiol.
  • 2008 Jun;30(1):128-136.
PURPOSE: To estimate the prevalence of co-prescribing contraindicated drugs for elderly patients in Busan. METHODS: We used the Health Insurance Review Agency (HIRA) claims database. Study population consisted of elderly patients...
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Antihyperglycemic agent combination therapy for patients with type 2 diabetes mellitus

Lee JM

Type 2 diabetes mellitus and diabetic complications have sharply increased and have become an important issue to resolve. The goal of treatment of type 2 diabetes is to prevent the...
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Mineral trioxied aggregate and its substitutes

Cho YB

Since its introduction in 1993, Mineral Trioxide Aggregate (MTA) has been shown to be superior to others in sealing, biocompatibility, and many other aspects of clinical endodontics. MTA is primarily...
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Serotonin Syndrome following Duloxetine Administration in a Fibromyalgia Patient: Case Report and Literature Review

Choi JS, Lee JH, Park SK, Shim BJ, Choi WK, Kim SH, Hwang SC

Serotonin syndrome, an adverse drug reaction, is a consequence of excess serotonergic agonism of central nervous system receptors and peripheral serotonergic receptors. Serotonin syndrome has been associated with large numbers...
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Failure of orthograde MTA filling: MTA wash-out?

Kim Y, Lee CY, Kim E, Jung IY

Mineral trioxide aggregate (MTA), which was originally developed for repair of root perforations, is a biocompatible material with numerous clinical applications in endodontics. MTA must be allowed to set in...
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Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines

Avila-Arroyo S, Nunez GS, Garcia-Fernandez LF, Galmarini

PURPOSE: Trabectedin induces synthetic lethality in tumor cells carrying defects in homologous recombinant DNA repair. We evaluated the effect of concomitant inhibition of nucleotide-excision repair and poly (ADP-ribose) polymerase (PARP)...
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Hexafluorenium-Succinylcholin Relaxation during Clinical Anesthesia

Park CY, Song SH, Oh HK

  • KMID: 2358217
  • Korean J Anesthesiol.
  • 1970 Jan;3(1):119-126.
Hexafluorenium was used to potentiat succinylcholine in 36 patients undergoing major surgery, mainly abdominal, of from 1/2 to 7 hours duration. Anesthesia consisted of thiopental-nitrous oxide-oxygen-ether or haIothane and ventilation...
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The recent trend of prenatal screening

Hwang D

  • KMID: 2184441
  • J Genet Med.
  • 2008 Jun;5(1):7-14.
Twenty years have passed since a prenatal screening for Down syndrome and neural tube defect was applied to obstetric field. The Quad test (AFP, hCG, uE3, Inhibin-A) of the second...
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The Interaction of Morphine and Adenosine Receptor Agonists on Antiallodynia in Rats with a Nerve Ligation Injury

Lee JR, Kim YK, Choi DK, Park JY, Kwak MJ, Hwang JH

BACKGROUND: A Nerve ligation injury may produce a pain syndrome that includes tactile allodynia. Reversal effects on tactile allodynia have been demonstrated after an intrathecal administration of adenosine...
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Comparison of Two Combinations of Maximum Medical Therapy for Lowering Intraocular Pressure in Primary Open-angle Glaucoma

Wy S, Kim YK, Jeoung JW, Park KH, Ha A

PURPOSE: We sought to compare the efficacy as well as the safety of two maximum medical therapy combinations applied to lower the intraocular pressure (IOP) in different primary open-angle glaucoma...
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